Protein Alignment lbe and HLX

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 443
• Identity: 106/443 - (23%)
• Similarity: 159/443 - (35%)
• Gaps: 158/443 - (35%)

  Fly    15 SEISVGGAPSPLPTQHHTHPHSHPHPLQHPRASTIDLLQQQQLLMQHH-------AAAAAAAAAA 72
            |....||...||          .|..::.|.....|:|         |       ||....|.|:
Human    23 SSAGPGGCSFPL----------DPAAVKKPSFCIADIL---------HAGVGDLGAAPEGLAGAS 68

  Fly    73 ASGLTRSAVGNLPEDYFHPLKRLRMSSSSSEPRDHTP-SPPSAVPE--PQTNQTTKSAIEGVKSF 134
            |:.|| :.:|::     ||  .....:::..|...|| ..||.||.  ||.          :...
Human    69 AAALT-AHLGSV-----HP--HASFQAAARSPLRPTPVVAPSEVPAGFPQR----------LSPL 115

  Fly   135 SIADILGHSEKQ------REESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAML 193
            |.|....|.::|      :::...|||.|..|.||||          ..|..|...|..:|.|
Human   116 SAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQPPAS----------GTRVVPNPHHSGSAPA-- 168

  Fly   194 LPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHM-------- 250
             ||.:.::                    ...::.|:.::..:::|     ...||.:
Human   169 -PSSKDLK--------------------FGIDRILSAEFDPKVKE-----GNTLRDLTSLLTGGR 207

  Fly   251 -------GMNPA---IIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKS 305
                   |:.|:   ..||.|..:|.|...|..|.     :||.:.:.:...|..|.
Human   208 PAGVHLSGLQPSAGQFFASLDPINEASAILSPLNS-----NPRNSVQHQFQDTFPGP-------- 259

  Fly   306 EEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRK--SRTAFTNHQIFEL 368
                               :.:.|||              ..||..|:::  ||..|:|.|...|
Human   260 -------------------YAVLTKD--------------TMPQTYKRKRSWSRAVFSNLQRKGL 291

  Fly   369 EKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIE-ELKKDFD 420
            ||||..|||::..||.::||.|||::|||..||||||.|.:...| :.:||.|
Human   292 EKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRHSKEAQAQKDKD 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	30/57 (53%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		19/67 (28%)
		Homeodomain	273..333	CDD:459649	31/59 (53%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		4/14 (29%)