DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment lbe and HHEX

DIOPT Version :10

Sequence 1:NP_524435.2 Gene:lbe / 42542 FlyBaseID:FBgn0011278 Length:479 Species:Drosophila melanogaster
Sequence 2:NP_002720.1 Gene:HHEX / 3087 HGNCID:4901 Length:270 Species:Homo sapiens


Alignment Length:374 Identity:89/374 - (23%)
Similarity:118/374 - (31%) Gaps:163/374 - (43%)


- Green bases have known domain annotations that are detailed below.


  Fly   108 TPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPIAPSG 172
            ||....|.|.|               |.|.||||..      ..:|.|     ||....|.:...
Human    21 TPLLQPAHPTP---------------FYIEDILGRG------PAAPTP-----APTLPSPNSSFT 59

  Fly   173 GLLQP-RT---EPLDVHP-------AAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQ 226
            .|:.| ||   ||..:||       ||.||...|.|        ..||..|              
Human    60 SLVSPYRTPVYEPTPIHPAFSHHSAAALAAAYGPGG--------FGGPLYP-------------- 102

  Fly   227 RLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKL 291
                 :.|.:.::.:|   ||||..:...::.|.                               
Human   103 -----FPRTVNDYTHA---LLRHDPLGKPLLWSP------------------------------- 128

  Fly   292 TTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKS 356
                                                                |..||..|:| ..
Human   129 ----------------------------------------------------FLQRPLHKRK-GG 140

  Fly   357 RTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDS 421
            :..|:|.|..||||:|..||||||.:|..:|..|.||..||.|||||||||.:|    ||::...
Human   141 QVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRR----LKQENPQ 201

  Fly   422 VKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPVPGS 470
                |..|..||:: |.|..:::.:......|   |:..:....|.|.|
Human   202 ----SNKKEELESL-DSSCDQRQDLPSEQNKG---ASLDSSQCSPSPAS 242

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbeNP_524435.2 Homeodomain 354..410 CDD:459649 30/55 (55%)
HHEXNP_002720.1 Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982 1..137 43/254 (17%)
Homeodomain 136..194 CDD:459649 32/58 (55%)
Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982 137..270 45/119 (38%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..270 14/61 (23%)

Return to query results.
Submit another query.