Protein Alignment lbe and GBX2

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001476.2
• Gene: GBX2 / 2637
• HGNCID: 4186
• Length: 348
• Species: Homo sapiens
• Alignment Length: 390
• Identity: 100/390 - (25%)
• Similarity: 133/390 - (34%)
• Gaps: 114/390 - (29%)

  Fly   111 PPS--AVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPP-PNAN-------------- 158
            |||  .:..|..:.|         :|||..::|          ||| |:..
Human     6 PPSLMMMQRPLGSST---------AFSIDSLIG----------SPPQPSPGHFVYTGYPMFMPYR 51

  Fly   159 --LLAPPASRPIAPSGGLLQPRTEPLDVH------PAAAAAML-------------LPSGQIVRP 202
              :|.||...|.|.....|||...|...|      |....:.|             ||.|....|
Human    52 PVVLPPPPPPPPALPQAALQPALPPAHPHHQIPSLPTGFCSSLAQGMALTSTLMATLPGGFSASP 116

  Fly   203 WDHLLGPTMPVRPFIPSALL---HYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSS 264
            ...   .....|.|.|..|.   ::::..||....:..:.|.|:...|........:.||..| :
Human   117 QHQ---EAAAARKFAPQPLPGGGNFDKAEALQADAEDGKGFLAKEGSLLAFSAAETVQASLVG-A 177

  Fly   265 ERSQRSSSSNGSTECCSPRQAEKLE---------KLTTQEG-SEEAQKKKSEEQPTGSGKSNGDT 319
            .|.|....|....:.....::..||         .||.|.. .||......||.|..||.:...|
Human   178 VRGQGKDESKVEDDPKGKEESFSLESDVDYSSDDNLTGQAAHKEEDPGHALEETPPSSGAAGSTT 242

  Fly   320 PLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRD 384
                                         ...|.|:.|||||:.|:.||||.|..:||||..:|.
Human   243 -----------------------------STGKNRRRRTAFTSEQLLELEKEFHCKKYLSLTERS 278

  Fly   385 EIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHES 449
            :||.:|.||..||..||||||||.||           ||..:|:....|...:..|:...|:|.|
Human   279 QIAHALKLSEVQVKIWFQNRRAKWKR-----------VKAGNANSKTGEPSRNPKIVVPIPVHVS 332

  Fly   450  449
            Human   333  332

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	32/55 (58%)
GBX2	NP_001476.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	59..81		6/21 (29%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	111..139		6/30 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	179..251		18/100 (18%)
		Homeodomain	248..304	CDD:459649	32/55 (58%)