Protein Alignment lbe and GBX1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001092304.1
• Gene: GBX1 / 2636
• HGNCID: 4185
• Length: 363
• Species: Homo sapiens
• Alignment Length: 379
• Identity: 91/379 - (24%)
• Similarity: 135/379 - (35%)
• Gaps: 122/379 - (32%)

  Fly   133 SFSIADILGHSEKQREESVSPPPNANLL---APPASRPIAP--SGGLLQPRTEPLDVHPAAAAAM 192
            :|||..::|          .|||.:..|   ..|...|..|  ....|.|...|..:.|.|..|.
Human    24 AFSIDSLIG----------PPPPRSGHLLYTGYPMFMPYRPLVLPQALAPAPLPAGLPPLAPLAS 78

  Fly   193 LLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAII 257
            .  :|::...:...||..:|....:.:||..:.:.....|..|                   .:.
Human    79 F--AGRLTNTFCAGLGQAVPSMVALTTALPSFAEPPDAFYGPQ-------------------ELA 122

  Fly   258 ASEDGSSERSQRSSSSNGSTECCSPRQAEKL----EKLT-----------------TQEG----S 297
            |:...::..:.|::...|........:|::|    ||:.                 ..||    |
Human   123 AAAAAAAATAARNNPEPGGRRPEGGLEADELLPAREKVAEPPPPPPPHFSETFPSLPAEGKVYSS 187

  Fly   298 EEAQKKKSEEQPTGSGK----SNGDTPLDALFQMTTKDFDESQDKSHLDIFSN------RPQPK- 351
            :|.:.:.|...|.||.:    |.||                |:|...||..:.      .|:||
Human   188 DEEKLEASAGDPAGSEQEEEGSGGD----------------SEDDGFLDSSAGGPGALLGPKPKL 236

  Fly   352 -----------------------KKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLS 393
                                   |.|:.|||||:.|:.||||.|..:||||..:|.:||.:|.||
Human   237 KGSLGTGAEEGAPVTAGVTAPGGKSRRRRTAFTSEQLLELEKEFHCKKYLSLTERSQIAHALKLS 301

  Fly   394 NAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMH 447
            ..||..||||||||.||           :|..:......|.|.:..|:...|:|
Human   302 EVQVKIWFQNRRAKWKR-----------IKAGNVSSRSGEPVRNPKIVVPIPVH 344

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	32/55 (58%)
GBX1	NP_001092304.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..31		3/6 (50%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	128..265		26/152 (17%)
		Homeodomain	262..318	CDD:459649	32/55 (58%)