DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbe and Npm1

DIOPT Version :9

Sequence 1:	NP_524435.2	Gene:	lbe / 42542	FlyBaseID:	FBgn0011278	Length:	479	Species:	Drosophila melanogaster
Sequence 2:	NP_037124.1	Gene:	Npm1 / 25498	RGDID:	3192	Length:	292	Species:	Rattus norvegicus

Alignment Length:	194	Identity:	29/194 - (14%)
Similarity:	69/194 - (35%)	Gaps:	45/194 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   249 HMGMNPAIIASEDGSSE------------RSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQ 301
            |:.....:...||..||            ..:||:...|:.   .|::..||::...::..::..
  Rat   110 HISGQHLVAVEEDAESEDEDEEDVKLLGMSGKRSAPGGGNK---VPQKKVKLDEDDDEDDEDDED 171

  Fly   302 KKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKK----KRKSRTAFTN 362
            .:..::......::....|:....:.|.....:..:::..|:..:.|:.|.    |::.:|..|.
  Rat   172 DEDDDDDDFDEEETEEKVPVKKSVRDTPAKNAQKSNQNGKDLKPSTPRSKGQESFKKQEKTPKTP 236

  Fly   363 HQIFELEKRFLYQKYLSPADRDEIAASLGLS----------NAQVITWFQN-RRAKQKRDIEEL 415
            .               .|:..::|.|.:..|          .|:.|.:.:| .|...:..|::|
  Rat   237 K---------------GPSSVEDIKAKMQASIEKGGSLPKVEAKFINYVKNCFRMTDQEAIQDL 285

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeobox	356..410	CDD:395001	10/64 (16%)
Npm1	NP_037124.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..185		11/77 (14%)
		Necessary for interaction with APEX1. /evidence=ECO:0000250	1..117		1/6 (17%)
		Nucleoplasmin	18..117	CDD:397268	1/6 (17%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..248		16/127 (13%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	190..196		1/5 (20%)
		Required for nucleolar localization. /evidence=ECO:0000250	241..292		9/45 (20%)
		NPM1-C	243..289	CDD:406641	9/43 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900