Protein Alignment lbe and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_075993.1
• Gene: Nkx2-4 / 228731
• MGIID: 97349
• Length: 354
• Species: Mus musculus
• Alignment Length: 302
• Identity: 76/302 - (25%)
• Similarity: 117/302 - (38%)
• Gaps: 84/302 - (27%)

  Fly   134 FSIADILGHSEKQREE-----SVSPPPNANLLAP------------PASRPIAPSGGLLQPRTEP 181
            ||::|||...|:..::     ..:||   .|.||            |:|:..|.:.|:..|..
Mouse    11 FSVSDILSPIEETYKKFGGVMDGAPP---GLGAPLGAAAYRAPPSGPSSQAAAVAAGMQPPHA-- 70

  Fly   182 LDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQL 246
            :..|.|||||....:........|:           |..:..:.       |..:..:.|..
Mouse    71 MAGHNAAAAAAAAAAAAAAAATYHM-----------PPGVSQFP-------HSAMGSYCNGG--- 114

  Fly   247 LRHMGMNPAIIASEDGSSERSQRSSSSNG----STECCSPRQAEKLEKLTTQEGSEEAQKKKSEE 307
            |.:||..||.   .||.  |...::::.|    :|:   ||.:.....:....|...|
Mouse   115 LGNMGELPAY---TDGM--RGGAAAAATGWYGANTD---PRYSSISRFMGPSAGVNVA------- 164

  Fly   308 QPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRF 372
               |.|...|..  ||.             ||...:.:..|    :||.|..|:..|::|||:||
Mouse   165 ---GMGSLTGIA--DAA-------------KSLAPLHAAAP----RRKRRVLFSQAQVYELERRF 207

  Fly   373 LYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEE 414
            ..|||||..:|:.:|:.:.|:..||..||||.|.|.||..::
Mouse   208 KQQKYLSAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	26/55 (47%)
Nkx2-4	NP_075993.1	Homeodomain	189..245	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		1/5 (20%)