Protein Alignment lbe and EN1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 431
• Identity: 96/431 - (22%)
• Similarity: 144/431 - (33%)
• Gaps: 147/431 - (34%)

  Fly    53 QQQQLLMQHHAAAAAAAAAAASGLTRS----AVGNLPEDYFHPLKRLRMSSSSSE-------PRD 106
            ||.:...|..:|..|||||...||:.|    |.|:              |.|.|:       |:.
Human     4 QQPEPKSQRDSALGAAAAATPGGLSLSLSPGASGS--------------SGSGSDGDSVPVSPQP 54

  Fly   107 HTPSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRP---- 167
            ..||||:|...|.                    |.|..........|||..  ||.||.:|
Human    55 APPSPPAAPCLPP--------------------LAHHPHLPPHPPPPPPQH--LAAPAHQPQPAA 97

  Fly   168 -------------IAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRPF--- 216
                         :.|..|..:.:..|..:..|||.......|::.|..........||.|.
Human    98 QLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTAAGRDPVHPLGTR 162

  Fly   217 IPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASED---GSSERSQRSSSSNGSTE 278
            .|.|                                 .:::.:.|   |..:.||.:::..|:::
Human   163 APGA---------------------------------ASLLCAPDANCGPPDGSQPAAAGAGASK 194

  Fly   279 CCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNG---------------DTPLDALFQMT 328
            ..:|..|...........:..|..|.|:   ||.|.|.|               ..|  |:..|.
Human   195 AGNPAAAAAAAAAAVAAAAAAAAAKPSD---TGGGGSGGGAGSPGAQGTKYPEHGNP--AILLMG 254

  Fly   329 TKD------FDESQDK-----SHLDIFSNRPQ--PK----KKRKS-------RTAFTNHQIFELE 369
            :.:      .|..|..     .:...:|:||.  |:    ||:|:       |||||..|:..|:
Human   255 SANGGPVVKTDSQQPLVWPAWVYCTRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLK 319

  Fly   370 KRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKR 410
            ..|...:|::...|..:|..|.|:.:|:..||||:|||.|:
Human   320 AEFQANRYITEQRRQTLAQELSLNESQIKIWFQNKRAKIKK 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	22/62 (35%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		34/131 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		6/31 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		7/23 (30%)
		Homeodomain	305..360	CDD:459649	21/54 (39%)
		Engrail_1_C_sig	361..391	CDD:431338	96/431 (22%)