DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbe and Npm1

DIOPT Version :9

Sequence 1:NP_524435.2 Gene:lbe / 42542 FlyBaseID:FBgn0011278 Length:479 Species:Drosophila melanogaster
Sequence 2:NP_032748.1 Gene:Npm1 / 18148 MGIID:106184 Length:292 Species:Mus musculus


Alignment Length:209 Identity:43/209 - (20%)
Similarity:63/209 - (30%) Gaps:71/209 - (33%)


- Green bases have known domain annotations that are detailed below.


  Fly   212 PVRPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPA------IIASE----DGSS-- 264
            |:||  .:.|...|.:...|||.::....|.....||.:.:...      |:.:|    :||.  
Mouse    11 PLRP--QNYLFGCELKADKDYHFKVDNDENEHQLSLRTVSLGAGAKDELHIVEAEAMNYEGSPIK 73

  Fly   265 ------ERSQRSSSSNGSTECCSP-----------------------RQAEKLE------KLTTQ 294
                  :.|.:.:.|.|..|...|                       ..||..:      ||...
Mouse    74 VTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDVKLLGM 138

  Fly   295 EGSEEA--------QKK-KSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQP 350
            .|...|        ||| |.:|......:.:.|...|     ...||||.:.:..:        |
Mouse   139 SGKRSAPGGGNKVPQKKVKLDEDDEDDDEDDEDDEDD-----DDDDFDEEETEEKV--------P 190

  Fly   351 KKKRKSRTAFTNHQ 364
            .||....|...|.|
Mouse   191 VKKSVRDTPAKNAQ 204

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lbeNP_524435.2 Homeobox 356..410 CDD:395001 3/9 (33%)
Npm1NP_032748.1 Required for interaction with SENP3. /evidence=ECO:0000250 1..185 37/180 (21%)
Necessary for interaction with APEX1. /evidence=ECO:0000250 1..117 20/107 (19%)
Nucleoplasmin 18..116 CDD:308605 17/97 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 138..248 19/80 (24%)
Nuclear localization signal. /evidence=ECO:0000255 152..157 3/4 (75%)
Nuclear localization signal. /evidence=ECO:0000255 190..196 3/5 (60%)
Required for nucleolar localization. /evidence=ECO:0000250 241..292
NPM1-C 243..291 CDD:318505
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0488
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.900

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