Protein Alignment lbe and Nkx2-6

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_035050.2
• Gene: Nkx2-6 / 18092
• MGIID: 97351
• Length: 289
• Species: Mus musculus
• Alignment Length: 284
• Identity: 64/284 - (22%)
• Similarity: 99/284 - (34%)
• Gaps: 99/284 - (34%)

  Fly   248 RHMGMNPAIIASEDGSSERSQRSSS-----------SNGSTECCSPRQAEKLEKLTTQEGSEEAQ 301
            |::.||     .|.|..|.|.|:.:           ..||.....|:         |..|:....
Mouse    42 RYLRMN-----QESGWFESSDRAQAVPFRCTWETVLEMGSNPVGEPQ---------TPPGTISRL 92

  Fly   302 KKKSEEQPTGSGKSNGDT----PLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTN 362
            ..::.....|.|..:||.    |:                       |.|.:|  :||||..|:.
Mouse    93 GARNPMTDRGVGNLSGDMRRGGPV-----------------------STRTRP--QRKSRVLFSQ 132

  Fly   363 HQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEELKKDFDSVKVFSA 427
            .|:..||:||..|:||:..:|:.:|::|.|::.||..||||||.|.|...:      |.....:.
Mouse   133 AQVLALERRFKQQRYLTAPEREHLASALQLTSTQVKIWFQNRRYKSKSQRQ------DQTLELAG 191

  Fly   428 HKSFLENVN-DLSILKKKPMHESDMVGL-----------------------------AAAAAAAG 462
            |......|. .:.:|..||..:.|:...                             .:|:|..|
Mouse   192 HPLAPRRVAVPVLVLDGKPCLDPDVAAFLGPYKATSPYSCFGGYAGTPYDASYASRCTSASAGPG 256

  Fly   463 MVVPV------PG---SVPMGGAP 477
            .:.|:      ||   :.|.|..|
Mouse   257 PLTPLASSGFSPGGQSAAPQGHLP 280

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	26/55 (47%)
Nkx2-6	NP_035050.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	75..125		13/83 (16%)
		Homeodomain	124..179	CDD:459649	26/54 (48%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..289		6/22 (27%)