Protein Alignment lbe and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_032726.1
• Gene: Nkx2-5 / 18091
• MGIID: 97350
• Length: 318
• Species: Mus musculus
• Alignment Length: 320
• Identity: 77/320 - (24%)
• Similarity: 116/320 - (36%)
• Gaps: 138/320 - (43%)

  Fly   109 PSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQRE----------ESVSPPPNANLLA-- 161
            || |:..|.|               ||:.|||...::||.          |:...|.:..|.|
Mouse     3 PS-PALTPTP---------------FSVKDILNLEQQQRSLASGDLSARLEATLAPASCMLAAFK 51

  Fly   162 PPA-SRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPVRP-FIPSALLHY 224
            |.| |.|.|.:.||.:.|.|   :.||              |......|..|..| |.|.|
Mouse    52 PEAYSGPEAAASGLAELRAE---MGPA--------------PSPPKCSPAFPAAPTFYPGA---- 95

  Fly   225 EQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLE 289
                                    :...:||    :|..:::.          |.|:.::|.:|:
Mouse    96 ------------------------YGDPDPA----KDPRADKK----------ELCALQKAVELD 122

  Fly   290 KLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKR 354
            |..| :|:|                                                ||:.:::|
Mouse   123 KAET-DGAE------------------------------------------------RPRARRRR 138

  Fly   355 KSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEE 414
            |.|..|:..|::|||:||..|:|||..:||::|:.|.|::.||..||||||.|.||..::
Mouse   139 KPRVLFSQAQVYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQD 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	28/55 (51%)
Nkx2-5	NP_032726.1	Homeodomain	144..194	CDD:459649	25/49 (51%)