Protein Alignment lbe and Nkx2-2

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_035049.1
• Gene: Nkx2-2 / 18088
• MGIID: 97347
• Length: 273
• Species: Mus musculus
• Alignment Length: 247
• Identity: 63/247 - (25%)
• Similarity: 88/247 - (35%)
• Gaps: 81/247 - (32%)

  Fly   260 EDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDAL 324
            ||||........|                      ||.|.|::    ..|.|.|      .|||:
Mouse    24 EDGSVAEGPEEES----------------------EGPEPAKR----AGPLGQG------ALDAV 56

  Fly   325 FQMTTKD-FDESQDKSHL-----------------------DIFSNRPQPK-------------- 351
            ..:..|. |.:|.|..:.                       |..|..|:|.
Mouse    57 QSLPLKSPFYDSSDNPYTRWLASTEGLQYSLHGLAASAPPQDSSSKSPEPSADESPDNDKETQGG 121

  Fly   352 -----KKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRD 411
                 ||||.|..|:..|.:|||:||..|:|||..:|:.:|:.:.|:..||..||||.|.|.||
Mouse   122 GGDAGKKRKRRVLFSKAQTYELERRFRQQRYLSAPEREHLASLIRLTPTQVKIWFQNHRYKMKR- 185

  Fly   412 IEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGM 463
             ...:|..:...:.|..:..:    .:.:...||.|......||||...||:
Mouse   186 -ARAEKGMEVTPLPSPRRVAV----PVLVRDGKPCHALKAQDLAAATFQAGI 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	25/55 (45%)
Nkx2-2	NP_035049.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..56		14/63 (22%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	91..131		7/39 (18%)
		Homeodomain	129..185	CDD:459649	25/55 (45%)