Protein Alignment lbe and DLX4

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_612138.1
• Gene: DLX4 / 1748
• HGNCID: 2917
• Length: 240
• Species: Homo sapiens
• Alignment Length: 260
• Identity: 65/260 - (25%)
• Similarity: 94/260 - (36%)
• Gaps: 103/260 - (39%)

  Fly   164 ASRPIAPSGGLLQP-----RTEPLDVHPAAAAAMLLPSGQIVRPWDHLLG-P-TMPVRPFIPSAL 221
            ||:.:.|.   |.|     ...||.:.|..||:   |:....||:.|||. | |.|..|  ..:.
Human    13 ASKAVFPD---LAPVPSVAAAYPLGLSPTTAAS---PNLSYSRPYGHLLSYPYTEPANP--GDSY 69

  Fly   222 LHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAE 286
            |..:|..||                                             |...|.|  ||
Human    70 LSCQQPAAL---------------------------------------------SQPLCGP--AE 87

  Fly   287 KLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQ-- 349
            ..::|       ||..:|....|..|                                ..|||
Human    88 HPQEL-------EADSEKPRLSPEPS--------------------------------ERRPQAP 113

  Fly   350 PKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEE 414
            .||.||.||.:::.|:..|.:||.:.:||:..:|.::||.|||:..||..||||:|:|.|:.:::
Human   114 AKKLRKPRTIYSSLQLQHLNQRFQHTQYLALPERAQLAAQLGLTQTQVKIWFQNKRSKYKKLLKQ 178

  Fly   415  414
            Human   179  178

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	24/55 (44%)
DLX4	NP_612138.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	80..120		16/80 (20%)
		Homeodomain	118..174	CDD:459649	24/55 (44%)