Protein Alignment lbe and DLX2

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_004396.1
• Gene: DLX2 / 1746
• HGNCID: 2915
• Length: 328
• Species: Homo sapiens
• Alignment Length: 278
• Identity: 68/278 - (24%)
• Similarity: 108/278 - (38%)
• Gaps: 86/278 - (30%)

  Fly   252 MNPAIIASEDGSSERSQRSS--------SSNGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQ 308
            |:...||:.....:..|..|        :|:.|:....|:::..|...|..:.|...    :::.
Human    12 MHSTQIAASSTYHQHQQPPSGGGAGPGGNSSSSSSLHKPQESPTLPVSTATDSSYYT----NQQH 72

  Fly   309 PTGSGKSNGDTPLDAL----FQMTTKDFDESQDKSHLDI------------------FSNRPQ-- 349
            |.|.| ..|.:|...:    :|.:..:......||..|:                  .:|.|:
Human    73 PAGGG-GGGGSPYAHMGSYQYQASGLNNVPYSAKSSYDLGYTAAYTSYAPYGTSSSPANNEPEKE 136

  Fly   350 ------------PKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQ 402
                        |||.||.||.:::.|:..|::||...:||:..:|.|:||||||:..||..|||
Human   137 DLEPEIRIVNGKPKKVRKPRTIYSSFQLAALQRRFQKTQYLALPERAELAASLGLTQTQVKIWFQ 201

  Fly   403 NRRAKQKRDIEELKKDFDSVKVFSAHKSFLENVNDLSILKKKPMHESDMVGLAAAAAAAGMVVPV 467
            |||:|       .||.:.|.::.|               ::.|       |.:|:...|...|..
Human   202 NRRSK-------FKKMWKSGEIPS---------------EQHP-------GASASPPCASPPVSA 237

  Fly   468 PGS----VPM----GGAP 477
            |.|    ||.    ||.|
Human   238 PASWDFGVPQRMAGGGGP 255

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	27/55 (49%)
DLX2	NP_004396.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	16..81		13/69 (19%)
		DLL_N	51..132	CDD:463567	12/85 (14%)
		Homeodomain	153..209	CDD:459649	27/62 (44%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	211..270		14/67 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	300..328