Protein Alignment lbe and NKX2-5

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_004378.1
• Gene: NKX2-5 / 1482
• HGNCID: 2488
• Length: 324
• Species: Homo sapiens
• Alignment Length: 310
• Identity: 76/310 - (24%)
• Similarity: 115/310 - (37%)
• Gaps: 117/310 - (37%)

  Fly   109 PSPPSAVPEPQTNQTTKSAIEGVKSFSIADILGHSEKQREESVSPPPNANLLAPPASRPIAPSGG 173
            || |:..|.|               ||:.|||...::||..:.:...:|.|.|     .:|||..
Human     3 PS-PALTPTP---------------FSVKDILNLEQQQRSLAAAGELSARLEA-----TLAPSSC 46

  Fly   174 LLQPRTEPLDVHPAAAAAMLLPS--GQIVR-PWDHLLGPTMPVRP-FIPSALLHYEQRLALDYHR 234
            :|..........|.|||.. ||.  .::.| |.........|..| |.|.|
Human    47 MLAAFKPEAYAGPEAAAPG-LPELRAELGRAPSPAKCASAFPAAPAFYPRA-------------- 96

  Fly   235 QLQEHFNAQAQLLRHMGMNPAIIASEDGSSERSQRSSSSNGSTECCSPRQAEKLEKLTTQEGSEE 299
                          :...:||    :|..:|:.          |.|:.::|.:||| |..:.:|
Human    97 --------------YSDPDPA----KDPRAEKK----------ELCALQKAVELEK-TEADNAE- 131

  Fly   300 AQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDKSHLDIFSNRPQPKKKRKSRTAFTNHQ 364
                                                           ||:.:::||.|..|:..|
Human   132 -----------------------------------------------RPRARRRRKPRVLFSQAQ 149

  Fly   365 IFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQNRRAKQKRDIEE 414
            ::|||:||..|:|||..:||::|:.|.|::.||..||||||.|.||..::
Human   150 VYELERRFKQQRYLSAPERDQLASVLKLTSTQVKIWFQNRRYKCKRQRQD 199

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	28/55 (51%)
NKX2-5	NP_004378.1	Homeodomain	145..195	CDD:459649	25/49 (51%)