Protein Alignment lbe and CDX1

DIOPT Version :10

• Sequence 1: NP_524435.2
• Gene: lbe / 42542
• FlyBaseID: FBgn0011278
• Length: 479
• Species: Drosophila melanogaster
• Sequence 2: NP_001795.2
• Gene: CDX1 / 1044
• HGNCID: 1805
• Length: 265
• Species: Homo sapiens
• Alignment Length: 267
• Identity: 67/267 - (25%)
• Similarity: 92/267 - (34%)
• Gaps: 88/267 - (32%)

  Fly   149 ESVSPPPNANLLAPPASRPIAPSGGLLQPRTEPLDVHPAAAAAMLLPSGQIVRPWDHLLGPTMPV 213
            ::..||      |||.:.|..|...... ..||....|.|..|   |.......|....||. |.
Human    28 QAYGPP------APPPAPPQYPDFSSYS-HVEPAPAPPTAWGA---PFPAPKDDWAAAYGPG-PA 81

  Fly   214 RPFIPSALLHYEQRLALDYHRQLQEHFNAQAQLLRHMGMNPAIIASEDG-----SSERSQRSSSS 273
            .|....|.|.:..  ..|:           :.:....|..|.::|...|     ||..:||
Human    82 APAASPASLAFGP--PPDF-----------SPVPAPPGPGPGLLAQPLGGPGTPSSPGAQR---- 129

  Fly   274 NGSTECCSPRQAEKLEKLTTQEGSEEAQKKKSEEQPTGSGKSNGDTPLDALFQMTTKDFDESQDK 338
                    |...|.:.:.....|.            .||||:.            |||
Human   130 --------PTPYEWMRRSVAAGGG------------GGSGKTR------------TKD------- 155

  Fly   339 SHLDIFSNRPQPKKKRKSRTAFTNHQIFELEKRFLYQKYLSPADRDEIAASLGLSNAQVITWFQN 403
                            |.|..:|:||..||||.|.|.:|::...:.|:||:|||:..||..||||
Human   156 ----------------KYRVVYTDHQRLELEKEFHYSRYITIRRKSELAANLGLTERQVKIWFQN 204

  Fly   404 RRAKQKR 410
            ||||:::
Human   205 RRAKERK 211

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbe	NP_524435.2	Homeodomain	354..410	CDD:459649	28/55 (51%)
CDX1	NP_001795.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	9..153		36/184 (20%)
		Caudal_act	13..142	CDD:461413	31/149 (21%)
		Homeodomain	156..211	CDD:459649	28/54 (52%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:28473536	157..178		10/20 (50%)
		Interaction with 5-mCpG DNA. /evidence=ECO:0000305|PubMed:28473536	196..207		7/10 (70%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	207..265		2/5 (40%)