DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbl and LBX2

DIOPT Version :9

Sequence 1:	NP_001262805.1	Gene:	lbl / 42541	FlyBaseID:	FBgn0008651	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_001269359.1	Gene:	LBX2 / 85474	HGNCID:	15525	Length:	198	Species:	Homo sapiens

Alignment Length:	154	Identity:	68/154 - (44%)
Similarity:	94/154 - (61%)	Gaps:	26/154 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   198 VPK--KSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNP---------KKK 251
            ||:  .:|:....|...:|   ||.||.:|::|.| ...|...|.....|:.|         :|:
Human    25 VPRAPSAPQLPESGPGPTS---PLCALEELTSKTF-RGLDARALQPSEGRAGPDALGPGPFGRKR 85

  Fly   252 RKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKD 316
            ||||||||.||:.|||:||::||||:|::||.:|..|||:||||:|||||||||||||:||::.|
Human    86 RKSRTAFTAQQVLELERRFVFQKYLAPSERDGLATRLGLANAQVVTWFQNRRAKLKRDVEEMRAD 150

  Fly   317 VQ----------CE-KIPDQSADP 329
            |.          |. .:|:.:.||
Human   151 VASLRALSPEVLCSLALPEGAPDP 174

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	65/144 (45%)
lbl	NP_001262805.1	Homeobox	254..307	CDD:278475	37/52 (71%)
LBX2	NP_001269359.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	24..46		6/23 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	63..89		6/25 (24%)
		Homeobox	88..141	CDD:278475	37/52 (71%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	173..198		2/2 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165141719
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472248at2759
OrthoFinder	1	1.000	-	-		FOG0002643
OrthoInspector	1	1.000	-	-		mtm8534
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24336
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5376
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.840