DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbl and BARX2

DIOPT Version :9

Sequence 1:	NP_001262805.1	Gene:	lbl / 42541	FlyBaseID:	FBgn0008651	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_003649.2	Gene:	BARX2 / 8538	HGNCID:	956	Length:	279	Species:	Homo sapiens

Alignment Length:	279	Identity:	71/279 - (25%)
Similarity:	100/279 - (35%)	Gaps:	101/279 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 LRSPISLEHDRQKSSPVRVKSFSIADILGRGHEEDRVEKKPERIAIPNALPGVPAPLALINERLQ 98
            |.||..|:..|:     |.|:|.|.:||.: ...|..||
Human     9 LSSPGQLKAARR-----RYKTFMIDEILSK-ETCDYFEK-------------------------- 41

  Fly    99 IPLVPNCPP----PAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASE 159
            :.|...||.    |..||:......|.:|                    .||..:|..|.:|:..
Human    42 LSLYSVCPSLVVRPKPLHSCTGSPSLRAY--------------------PLLSVITRQPTVISHL 86

  Fly   160 DGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQ 224
            ..::....::.|.:..||..|                       .|.|.|.:.:|.::
Human    87 VPATPGIAQALSCHQVTEAVS-----------------------AEAPGGEALASSES------- 121

  Fly   225 LSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLG 289
                   |.:.|.        ...||.|:|||.||..|:..|||:|..|||||..||.::|..||
Human   122 -------ETEQPT--------PRQKKPRRSRTIFTELQLMGLEKKFQKQKYLSTPDRLDLAQSLG 171

  Fly   290 LSNAQVITWFQNRRAKLKR 308
            |:..||.||:||||.|.|:
Human   172 LTQLQVKTWYQNRRMKWKK 190

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	39/103 (38%)
lbl	NP_001262805.1	Homeobox	254..307	CDD:278475	30/52 (58%)
BARX2	NP_003649.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	110..137		8/48 (17%)
		Homeobox	136..189	CDD:306543	30/52 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	194..279
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.810