Protein Alignment lbl and NKX6-2

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_796374.2
• Gene: NKX6-2 / 84504
• HGNCID: 19321
• Length: 277
• Species: Homo sapiens
• Alignment Length: 135
• Identity: 44/135 - (32%)
• Similarity: 66/135 - (48%)
• Gaps: 30/135 - (22%)

  Fly   250 KKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKR----DM 310
            ||:.||..|:.||||.|||.|...|||:..:|..:|..||::.:||..||||||.|.::    :|
Human   147 KKKHSRPTFSGQQIFALEKTFEQTKYLAGPERARLAYSLGMTESQVKVWFQNRRTKWRKRHAVEM 211

  Fly   311 EELKKDVQCEKIPDQSADPNRSHHNHPHYHQQHQHYAHMQSIGSDRDMDKDRCREKEKDKDKEEL 375
            ...||        .|.:|..:                 ::..|||.:.|.:..|..:.:.|.|::
Human   212 ASAKK--------KQDSDAEK-----------------LKVGGSDAEDDDEYNRPLDPNSDDEKI 251

  Fly   376 -RMLK 379
             |:||
Human   252 TRLLK 256

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	34/85 (40%)
		Homeodomain	252..308	CDD:459649	27/55 (49%)
NKX6-2	NP_796374.2	Repressor domain. /evidence=ECO:0000250|UniProtKB:D3Z4R4	89..142
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..155		4/7 (57%)
		Homeodomain	147..205	CDD:459649	29/57 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	210..250		11/64 (17%)