Protein Alignment lbl and nkx2.1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_571851.1
• Gene: nkx2.1 / 81883
• ZFINID: ZDB-GENE-010404-1
• Length: 346
• Species: Danio rerio
• Alignment Length: 354
• Identity: 83/354 - (23%)
• Similarity: 132/354 - (37%)
• Gaps: 107/354 - (30%)

  Fly    48 SPVRVKSFSIADILGRGHEEDRVEKKPERIAIPNALPGVPAPLALINERLQIPLVPNCPPPAALH 112
            ||.....||::|||      ..:|:..:::::.....|  ||||
Zfish     4 SPKHTTPFSVSDIL------SPLEESYKKVSMEGNNLG--APLA--------------------- 39

  Fly   113 TFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSS--NGS 175
                     ||.|...  .|..:|:|...     ...|:..|...:..|.|:.|..:...  ||:
Zfish    40 ---------SYRQPQV--TQAAMQQHHMG-----HNGTVPAAYHMTAAGVSQLSHTAMGGYCNGN 88

  Fly   176 TECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASK---SSGDTPLDALFQLST-KNFDEEQDP 236
            ....|...|.:...|...........:|:.:....|:   ||....:.::..||: .:..:...|
Zfish    89 LGNMSDLPAYQDGMRGSTTATSWYGTNPDPRFSTISRFMGSSSGMNMGSMSTLSSLADVGKGMGP 153

  Fly   237 ATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQN 301
            .|       |.|::||  |..|:..|::|||:||..|||||..:|:.:|..:.|:..||..||||
Zfish   154 LT-------STPRRKR--RVLFSQAQVYELERRFKQQKYLSAPEREHLASMIHLTPTQVKIWFQN 209

  Fly   302 RRAKLKR------DMEELKKD-VQCEK---------IP----------DQSADPNRSHHNHPHYH 340
            .|.|:||      ..:::::| ..|::         :|          ..|..||....|  |:|
Zfish   210 HRYKMKRQAKDKVSQQQMQQDNGSCQQQQQSPRRVAVPVLVKDGKPCQGSSHTPNTGVQN--HHH 272

  Fly   341 Q---------------QHQHYAHMQSIGS 354
            |               |||    .|.:||
Zfish   273 QGGNVMFMTNTSLSMSQHQ----SQQVGS 297

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	43/155 (28%)
		Homeodomain	252..308	CDD:459649	25/55 (45%)
nkx2.1	NP_571851.1	Homeodomain	160..216	CDD:459649	26/57 (46%)