DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbl and Lbx1

DIOPT Version :9

Sequence 1:	NP_001262805.1	Gene:	lbl / 42541	FlyBaseID:	FBgn0008651	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_001040573.1	Gene:	Lbx1 / 499362	RGDID:	1564197	Length:	285	Species:	Rattus norvegicus

Alignment Length:	251	Identity:	100/251 - (39%)
Similarity:	123/251 - (49%)	Gaps:	75/251 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    82 ALPGVPAPLALINERLQIPLVPNCPPPAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLL 146
            |.||        .||.:.|| .:.||||..:..|:|   .|.|..|.
  Rat     9 AAPG--------EERRRSPL-DHLPPPANSNKPLTP---FSIEDILN------------------ 43

  Fly   147 RQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQP-KGA 210
                 .|::           :||.|..|:....:...                |.:|...| .|.
  Rat    44 -----KPSV-----------RRSYSLCGAAHLLAAAD----------------KHAPGGLPLAGR 76

  Fly   211 SKSSGDTPLDALFQLSTKNFD----------EEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFE 265
            :..|..:||.||.:|::|.|.          |.:|..|  ||..|..|||:|||||||||.||:|
  Rat    77 ALLSQTSPLCALEELASKTFKGLEVSVLQAAEGRDGMT--IFGQRQTPKKRRKSRTAFTNHQIYE 139

  Fly   266 LEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEK 321
            |||||||||||||||||:||..|||:||||||||||||||||||:||:|.||:..|
  Rat   140 LEKRFLYQKYLSPADRDQIAQQLGLTNAQVITWFQNRRAKLKRDLEEMKADVESAK 195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	77/127 (61%)
lbl	NP_001262805.1	Homeobox	254..307	CDD:278475	46/52 (88%)
Lbx1	NP_001040573.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..36		13/38 (34%)
		Homeobox	128..181	CDD:278475	46/52 (88%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	212..285
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335405
Domainoid	1	1.000	107	1.000	Domainoid score	I6393
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1472248at2759
OrthoFinder	1	1.000	-	-		FOG0002643
OrthoInspector	1	1.000	-	-		mtm9009
orthoMCL	1	0.900	-	-		OOG6_107037
Panther	1	1.100	-	-	O	PTHR24336
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X3367
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	12	11.710