DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbl and NPM1

DIOPT Version :9

Sequence 1:	NP_001262805.1	Gene:	lbl / 42541	FlyBaseID:	FBgn0008651	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_001341935.1	Gene:	NPM1 / 4869	HGNCID:	7910	Length:	294	Species:	Homo sapiens

Alignment Length:	262	Identity:	47/262 - (17%)
Similarity:	87/262 - (33%)	Gaps:	66/262 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GVPAPLALINERLQI-PLVP----NCPPPAALHTFLSPALLHSYEQRL-AWDYQRQLQEHFQAQA 143
            |.|..:.|...::.: |.|.    ...||..|........:|...|.| |.:...:.::..:...
Human    69 GSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEEEEDV 133

  Fly   144 QLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPE---- 204
            :||                |...:||:...|     |....:||:..:.||..:..::..:
Human   134 KLL----------------SISGKRSAPGGG-----SKVPQKKVKLAADEDDDDDDEEDDDEDDD 177

  Fly   205 ---------EQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTN 260
                     |:.....||..|||.... |.|.:|..:.:..:|.......|..|:::..:|....
Human   178 DDDFDDEEAEEKAPVKKSIRDTPAKNA-QKSNQNGKDSKPSSTPRSKGQESFKKQEKTPKTPKGP 241

  Fly   261 QQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKIPDQ 325
            ..:.:::.:.  |..:      |..|.|....|:.|.:.:|                 |.::.||
Human   242 SSVEDIKAKM--QASI------EKGGSLPKVEAKFINYVKN-----------------CFRMTDQ 281

  Fly   326 SA 327
            .|
Human   282 EA 283

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	23/122 (19%)
lbl	NP_001262805.1	Homeobox	254..307	CDD:278475	8/52 (15%)
NPM1	NP_001341935.1	Required for interaction with SENP3	1..186		23/137 (17%)
		Necessary for interaction with APEX1. /evidence=ECO:0000269\|PubMed:19188445	1..117		10/47 (21%)
		Nucleoplasmin	18..117	CDD:397268	10/47 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	120..247		24/148 (16%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	191..197		2/5 (40%)
		Required for nucleolar localization	243..294		11/66 (17%)
		NPM1-C	245..291	CDD:406641	11/64 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900