Protein Alignment lbl and NKX1-2

DIOPT Version :9

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001139812.1
• Gene: NKX1-2 / 390010
• HGNCID: 31652
• Length: 310
• Species: Homo sapiens
• Alignment Length: 286
• Identity: 70/286 - (24%)
• Similarity: 106/286 - (37%)
• Gaps: 98/286 - (34%)

  Fly    46 KSSPVRVK-SFSIADILGRGHEEDRVEKKPERIAIPNALPGV-PAPLALINERLQIPLVPNCPPP 108
            |::|...| |||:.|||           .|::.. ..|||.| |||.
Human    10 KAAPSHHKISFSVLDIL-----------DPQKFT-RAALPAVRPAPR------------------ 44

  Fly   109 AALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQR----- 168
                                 :.::.|.|                 :.|.:|.||....|
Human    45 ---------------------EARKSLAE-----------------VEAGKDASSRDPVRQLETP 71

  Fly   169 SSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSG-----DTPLDALFQLSTK 228
            .::..|:.: .||.:..:.|   :|:..|.|:: |..:.:.|....|     |.|..||  .|.:
Human    72 DAAGPGAGQ-ASPLEGSEAE---EEEDAEDPRR-PRLRERAARLLPGLARSPDAPAGAL--ASGE 129

  Fly   229 NFDE---------EQDPATLNIFATRSNPK--KKRKSRTAFTNQQIFELEKRFLYQKYLSPADRD 282
            ..::         ...|.:......|..|.  |.|::|||||.:|:..||.:|...:|||..:|.
Human   130 PCEDGGGGPVRSPPGSPGSPRPRRRRLEPNCAKPRRARTAFTYEQLVALENKFRATRYLSVCERL 194

  Fly   283 EIAGGLGLSNAQVITWFQNRRAKLKR 308
            .:|..|.|:..||..||||||.|.|:
Human   195 NLALSLSLTETQVKIWFQNRRTKWKK 220

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	38/119 (32%)
		Homeobox	254..307	CDD:278475	25/52 (48%)
NKX1-2	NP_001139812.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	36..165		32/191 (17%)
		Homeobox	167..219	CDD:278475	25/51 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	217..260		2/4 (50%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.900