Protein Alignment lbl and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: XP_038962557.1
• Gene: Nkx2-4 / 366213
• RGDID: 1304985
• Length: 353
• Species: Rattus norvegicus
• Alignment Length: 291
• Identity: 72/291 - (24%)
• Similarity: 108/291 - (37%)
• Gaps: 72/291 - (24%)

  Fly    48 SPVRVKSFSIADILGRGHEEDRVEKKPERI--AIPNALPGVPAPLALINERL-------QIPLVP 103
            ||.....||::|||      ..:|:..::.  .:..|.||:.|||.....|.       |...|.
  Rat     4 SPKHTTPFSVSDIL------SPIEETYKKFGGVMDGAPPGLGAPLGAAAYRAPPTGPSSQAAAVA 62

  Fly   104 NCPPPAAL--HTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERS 166
            ...||.|:  |...:.|...:.....|..|.                  :.|.:          |
  Rat    63 GMQPPHAMAGHNAAAAAAAAAAAAAAAATYH------------------MPPGV----------S 99

  Fly   167 QRSSSSNGSTECCSPTQAEKVEKRSQEDRME---------------VPKKSPEEQPKGASKSSGD 216
            |...|:.||  .|:.......|..:..|.|.               .|:.|...:..|.|.....
  Rat   100 QFPHSAMGS--YCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDPRYSSISRFMGPSAGVNV 162

  Fly   217 TPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADR 281
            ..:.:|..::    |..:..|.|:..|.|      ||.|..|:..|::|||:||..|||||..:|
  Rat   163 AGMGSLTGIA----DAAKSLAPLHAAAPR------RKRRVLFSQAQVYELERRFKQQKYLSAPER 217

  Fly   282 DEIAGGLGLSNAQVITWFQNRRAKLKRDMEE 312
            :.:|..:.|:..||..||||.|.|:||..::
  Rat   218 EHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 248

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	36/107 (34%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
Nkx2-4	XP_038962557.1	Homeodomain	188..244	CDD:459649	26/55 (47%)