Protein Alignment lbl and PDX1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_000200.1
• Gene: PDX1 / 3651
• HGNCID: 6107
• Length: 283
• Species: Homo sapiens
• Alignment Length: 258
• Identity: 67/258 - (25%)
• Similarity: 91/258 - (35%)
• Gaps: 88/258 - (34%)

  Fly    80 PNALPGVPAPLALINERLQIPLVPNC------PPPAALHTFLSPALLHSYEQRLAWD---YQ--- 132
            |.|....|||     |....|  |.|      |||...|.|  |..|.:.||....|   |:
Human    17 PCAFQRGPAP-----EFSASP--PACLYMGRQPPPPPPHPF--PGALGALEQGSPPDISPYEVPP 72

  Fly   133 -------RQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKR 190
                   ..|..|..||. .|......|....:|.|..|
Human    73 LADDPAVAHLHHHLPAQL-ALPHPPAGPFPEGAEPGVLE-------------------------- 110

  Fly   191 SQEDRMEVP---KKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKR 252
             :.:|:::|   .||.:........:.|                           |..:.|::.:
Human   111 -EPNRVQLPFPWMKSTKAHAWKGQWAGG---------------------------AYAAEPEENK 147

  Fly   253 KSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKK 315
            ::|||:|..|:.||||.||:.||:|...|.|:|..|.|:...:..||||||.|.|:  ||.||
Human   148 RTRTAYTRAQLLELEKEFLFNKYISRPRRVELAVMLNLTERHIKIWFQNRRMKWKK--EEDKK 208

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	34/110 (31%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
PDX1	NP_000200.1	Transactivation domain. /evidence=ECO:0000250	13..73		20/64 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	34..71		12/38 (32%)
		Antp-type hexapeptide	118..123		1/4 (25%)
		Homeodomain	147..203	CDD:459649	26/55 (47%)
		Nuclear localization signal. /evidence=ECO:0000250	197..203		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	201..283		5/10 (50%)