Protein Alignment lbl and HOXD13

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_000514.2
• Gene: HOXD13 / 3239
• HGNCID: 5136
• Length: 343
• Species: Homo sapiens
• Alignment Length: 274
• Identity: 64/274 - (23%)
• Similarity: 96/274 - (35%)
• Gaps: 71/274 - (25%)

  Fly    91 ALINERLQIPLVPNCPPP----AALHTFLSPALLHSYEQRLAWDYQRQLQEHF--------QAQA 143
            |::..|.:.|....||.|    ||.....:|||.:.|              ||        .:..
Human    93 AVVAARPEAPPAKECPAPTPAAAAAAPPSAPALGYGY--------------HFGNGYYSCRMSHG 143

  Fly   144 QLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPK 208
            ..|:|..|..:..||..|.........|...|    |...|.:|..|::|........||.:...
Human   144 VGLQQNALKSSPHASLGGFPVEKYMDVSGLAS----SSVPANEVPARAKEVSFYQGYTSPYQHVP 204

  Fly   209 G-----ASKSSGDTPLDALFQLSTKNFDEEQDPATL------NIFATRSNP-------------- 248
            |     ::..||:...:|...:      |.....||      .::.|:..|
Human   205 GYIDMVSTFGSGEPRHEAYISM------EGYQSWTLANGWNSQVYCTKDQPQGSHFWKSSFPGDV 263

  Fly   249 ----------KKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRR 303
                      ::.||.|..:|..|:.|||..:...|:::...|..|:....||..||..||||||
Human   264 ALNQPDMCVYRRGRKKRVPYTKLQLKELENEYAINKFINKDKRRRISAATNLSERQVTIWFQNRR 328

  Fly   304 AKLKRDMEELKKDV 317
            .|.|:.:.:||..|
Human   329 VKDKKIVSKLKDTV 342

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	35/147 (24%)
		Homeodomain	252..308	CDD:459649	22/55 (40%)
HOXD13	NP_000514.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..28
		polyalanine repeat	57..71
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	78..115		6/21 (29%)
		HoxA13_N	<100..172	CDD:463521	18/85 (21%)
		Homeodomain	277..333	CDD:459649	22/55 (40%)