Protein Alignment lbl and HOXD3

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_008829.3
• Gene: HOXD3 / 3232
• HGNCID: 5137
• Length: 432
• Species: Homo sapiens
• Alignment Length: 224
• Identity: 59/224 - (26%)
• Similarity: 92/224 - (41%)
• Gaps: 38/224 - (16%)

  Fly   106 PPPAALHTFLSPALLHSYEQRLAWDYQR---QLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQ 167
            |||||..:             |..||..   .:|.....:|...:...||.:.:....|:|:...
Human    51 PPPAAASS-------------LDTDYPGSACSIQSSAPLRAPAHKGAELNGSCMRPGTGNSQGGG 102

  Fly   168 RSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKS--------PEEQPKGA--SKSSGDTPLDAL 222
            ..|...|       ..:|:...:.......:|..|        |.::|||.  :.||..|....:
Human   103 GGSQPPG-------LNSEQQPPQPPPPPPTLPPSSPTNPGGGVPAKKPKGGPNASSSSATISKQI 160

  Fly   223 F---QLSTKNFDEEQDPATLNIFATRSNP--KKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRD 282
            |   :.|.:|..::...||........:|  ...::.|||:|:.|:.||||.|.:.:||....|.
Human   161 FPWMKESRQNSKQKNSCATAGESCEDKSPPGPASKRVRTAYTSAQLVELEKEFHFNRYLCRPRRV 225

  Fly   283 EIAGGLGLSNAQVITWFQNRRAKLKRDME 311
            |:|..|.|:..|:..||||||.|.|:|.:
Human   226 EMANLLNLTERQIKIWFQNRRMKYKKDQK 254

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	39/113 (35%)
		Homeodomain	252..308	CDD:459649	25/55 (45%)
HOXD3	NP_008829.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	43..62		6/23 (26%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	68..197		24/135 (18%)
		Antp-type hexapeptide	160..165		1/4 (25%)
		Homeodomain	195..251	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	253..280		0/2 (0%)
		DUF4074	369..430	CDD:463833
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	400..432