Protein Alignment lbl and HOXC11

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_055027.1
• Gene: HOXC11 / 3227
• HGNCID: 5123
• Length: 304
• Species: Homo sapiens
• Alignment Length: 276
• Identity: 59/276 - (21%)
• Similarity: 102/276 - (36%)
• Gaps: 57/276 - (20%)

  Fly    74 PERIAIPNALPGVPAPLALINERLQIPLVPNCPPPAALHTFLSPALLHSYEQRLAWDYQRQLQEH 138
            ||...:.:.||..|      :.::..|.....||...:...|.|:        ..|.::......
Human    42 PEFSTVSSFLPQAP------SRQISYPYSAQVPPVREVSYGLEPS--------GKWHHRNSYSSC 92

  Fly   139 FQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKS- 202
            :.|..:|:.:..|.|:.:      :|...::..|.|.....|...|......|..::..|..::
Human    93 YAAADELMHRECLPPSTV------TEILMKNEGSYGGHHHPSAPHATPAGFYSSVNKNSVLPQAF 151

  Fly   203 --------------PEEQP---KGASKSSGDT-PLDALFQLSTKNFDEEQDPATLNIFATRS--- 246
                          |.|.|   ||.:|...:. |...|...:....:.|.:....|..::.|
Human   152 DRFFDNAYCGGGDPPAEPPCSGKGEAKGEPEAPPASGLASRAEAGAEAEAEEENTNPSSSGSAHS 216

  Fly   247 -----------NPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQ 300
                       |..:.||.|..::..||.|||:.|.:..|::...|.:::..|.|::.||..|||
Human   217 VAKEPAKGAAPNAPRTRKKRCPYSKFQIRELEREFFFNVYINKEKRLQLSRMLNLTDRQVKIWFQ 281

  Fly   301 NRRAKLKRDMEELKKD 316
            |||.|.|:    |.:|
Human   282 NRRMKEKK----LSRD 293

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	35/129 (27%)
		Homeodomain	252..308	CDD:459649	22/55 (40%)
HOXC11	NP_055027.1	DUF3528	42..161	CDD:432284	22/138 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	166..237		14/70 (20%)
		Homeodomain	233..289	CDD:459649	22/55 (40%)