Protein Alignment lbl and HOXB8

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_076921.1
• Gene: HOXB8 / 3218
• HGNCID: 5119
• Length: 243
• Species: Homo sapiens
• Alignment Length: 228
• Identity: 55/228 - (24%)
• Similarity: 90/228 - (39%)
• Gaps: 46/228 - (20%)

  Fly   117 PALLHSYEQRLAWDYQRQLQEHFQAQAQL-LRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCS 180
            |.:::......::.:..|:||.:...:.| ......||..:|..           ...|:.....
Human    36 PTVVYGPSSGGSFQHPSQIQEFYHGPSSLSTAPYQQNPCAVACH-----------GDPGNFYGYD 89

  Fly   181 PTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATR 245
            |.|.:.:......|.::.                .|..|.|...|..:....||.|:...:|..
Human    90 PLQRQSLFGAQDPDLVQY----------------ADCKLAAASGLGEEAEGSEQSPSPTQLFPW- 137

  Fly   246 SNPKK---KRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLK 307
            ..|:.   :|:.|..::..|..||||.||:..||:...|.|::..|||:..||..||||||.|.|
Human   138 MRPQAAAGRRRGRQTYSRYQTLELEKEFLFNPYLTRKRRIEVSHALGLTERQVKIWFQNRRMKWK 202

  Fly   308 R------------DMEELKKDVQCEKIPDQSAD 328
            :            :.|||:|. :.|:.| ::||
Human   203 KENNKDKFPSSKCEQEELEKQ-KLERAP-EAAD 233

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	43/138 (31%)
		Homeodomain	252..308	CDD:459649	25/55 (45%)
HOXB8	NP_076921.1	Antp-type hexapeptide	134..139		1/5 (20%)
		Homeodomain	147..203	CDD:459649	25/55 (45%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	203..243		8/33 (24%)