Protein Alignment lbl and HOXB2

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_002136.1
• Gene: HOXB2 / 3212
• HGNCID: 5113
• Length: 356
• Species: Homo sapiens
• Alignment Length: 242
• Identity: 64/242 - (26%)
• Similarity: 96/242 - (39%)
• Gaps: 53/242 - (21%)

  Fly   129 WDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSS-------------ERSQRSSSSNGSTECCS 180
            ::::|:: ....:|..|...:|..||::.:...||             |::..|.....||
Human     3 FEFEREI-GFINSQPSLAECLTSFPAVLETFQTSSIKESTLIPPPPPFEQTFPSLQPGAST---- 62

  Fly   181 PTQAEKVEKRSQEDRMEVPKKSPEEQP--------------KGASK--SSGDTPLDALFQLSTKN 229
             .|..:.:||: ||...:|...|...|              |.|.|  .|..:|..|...:....
Human    63 -LQRPRSQKRA-EDGPALPPPPPPPLPAAPPAPEFPWMKEKKSAKKPSQSATSPSPAASAVPASG 125

  Fly   230 FDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQ 294
            .....|...|    ..:.....|:.|||:||.|:.||||.|.:.|||....|.|||..|.|:..|
Human   126 VGSPADGLGL----PEAGGGGARRLRTAYTNTQLLELEKEFHFNKYLCRPRRVEIAALLDLTERQ 186

  Fly   295 VITWFQNRRAKLKRDMEELK------------KDVQCEKIPDQSADP 329
            |..||||||.|.||..:..:            :|: |:...:.:|.|
Human   187 VKVWFQNRRMKHKRQTQHREPPDGEPACPGALEDI-CDPAEEPAASP 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	45/152 (30%)
		Homeodomain	252..308	CDD:459649	30/55 (55%)
HOXB2	NP_002136.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	39..142		20/112 (18%)
		Antp-type hexapeptide	94..99		0/4 (0%)
		Homeodomain	144..200	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	197..240		7/37 (19%)