Protein Alignment lbl and HOXA11

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_005514.1
• Gene: HOXA11 / 3207
• HGNCID: 5101
• Length: 313
• Species: Homo sapiens
• Alignment Length: 360
• Identity: 83/360 - (23%)
• Similarity: 128/360 - (35%)
• Gaps: 113/360 - (31%)

  Fly     1 MPQRTPS--PANSDVSVGSPSPPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIADILGR 63
            :|| |||  |.....|...|...|:|.:..:...:  .|.:..|.|...:    ..:|..:::.|
Human    34 LPQ-TPSSRPMTYSYSSNLPQVQPVREVTFREYAI--EPATKWHPRGNLA----HCYSAEELVHR 91

  Fly    64 GHEEDRVEKKPERIAIPNALPGVPAP-LALINERLQIPLVPNCPPPAALHTFLSP-----ALLHS 122
                       :.:..|:| .|||.. ||..:..     |.:.|.||....|.|.     .|..:
Human    92 -----------DCLQAPSA-AGVPGDVLAKSSAN-----VYHHPTPAVSSNFYSTVGRNGVLPQA 139

  Fly   123 YEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQR------------------- 168
            ::|.....|.                   .|..:||.|...::|..
Human   140 FDQFFETAYG-------------------TPENLASSDYPGDKSAEKGPPAATATSAAAAAAATG 185

  Fly   169 ----SSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKN 229
                |||.:|....|..|.|...||  :..|......|||       .|||.|
Human   186 APATSSSDSGGGGGCRETAAAAEEK--ERRRRPESSSSPE-------SSSGHT------------ 229

  Fly   230 FDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQ 294
              |::        |..|:.::.||.|..:|..||.|||:.|.:..|::...|.:::..|.|::.|
Human   230 --EDK--------AGGSSGQRTRKKRCPYTKYQIRELEREFFFSVYINKEKRLQLSRMLNLTDRQ 284

  Fly   295 VITWFQNRRAKLKRDMEELKKDVQCEKIPDQSADP 329
            |..||||||.|        :|.:..:::...||:|
Human   285 VKIWFQNRRMK--------EKKINRDRLQYYSANP 311

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	34/124 (27%)
		Homeodomain	252..308	CDD:459649	23/55 (42%)
HOXA11	NP_005514.1	DUF3528	25..153	CDD:432284	32/161 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	154..246		26/122 (21%)
		Homeodomain	242..298	CDD:459649	23/63 (37%)