Protein Alignment lbl and HOXA4

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_002132.3
• Gene: HOXA4 / 3201
• HGNCID: 5105
• Length: 320
• Species: Homo sapiens
• Alignment Length: 302
• Identity: 80/302 - (26%)
• Similarity: 111/302 - (36%)
• Gaps: 69/302 - (22%)

  Fly    80 PNALPGVPAPLALINERLQIPLVPNCPPPAALHTFL-SPALLHS---YEQRLAWDYQRQLQEHFQ 140
            |...||...|                |.|...|..| .|.|.|:   .|...::...|..:|...
Human    36 PGGGPGYQQP----------------PAPPTQHLPLQQPQLPHAGGGREPTASYYAPRTAREPAY 84

  Fly   141 AQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQ-------EDRMEV 198
            ..|      .|.||..|: |.:.....|..:|.|     .|.|.|:...:::       ...:..
Human    85 PAA------ALYPAHGAA-DTAYPYGYRGGASPG-----RPPQPEQPPAQAKGPAHGLHASHVLQ 137

  Fly   199 PKKSPEEQPKGASKSS----------------GDTPLDALF-----QLSTKNFDEEQDPATLNIF 242
            |:..|..||:....::                |..|...|.     .|..|..:....|....|.
Human   138 PQLPPPLQPRAVPPAAPRRCEAAPATPGVPAGGSAPACPLLLADKSPLGLKGKEPVVYPWMKKIH 202

  Fly   243 ATRSNPK----KKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRR 303
            .:..||.    :.::||||:|.||:.||||.|.:.:||:...|.|||..|.||..||..||||||
Human   203 VSAVNPSYNGGEPKRSRTAYTRQQVLELEKEFHFNRYLTRRRRIEIAHTLCLSERQVKIWFQNRR 267

  Fly   304 AKLKRDMEELKKDVQCEKIPDQSADP-----NRSHHNHPHYH 340
            .|.|:|.:.....::.......||.|     .:|.|.|||.|
Human   268 MKWKKDHKLPNTKMRSSNSASASAGPPGKAQTQSPHLHPHPH 309

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	46/155 (30%)
		Homeodomain	252..308	CDD:459649	30/55 (55%)
HOXA4	NP_002132.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	19..77		12/56 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	101..168		10/71 (14%)
		Antp-type hexapeptide	194..199		1/4 (25%)
		Homeodomain	216..272	CDD:459649	30/55 (55%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	273..320		10/37 (27%)