Protein Alignment lbl and HOXA1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_005513.2
• Gene: HOXA1 / 3198
• HGNCID: 5099
• Length: 335
• Species: Homo sapiens
• Alignment Length: 256
• Identity: 71/256 - (27%)
• Similarity: 90/256 - (35%)
• Gaps: 78/256 - (30%)

  Fly    88 APLALINERLQIPLVPNCPPPAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLN 152
            :|.||..|.......|.|.|........||.:.|.:              |.|..|   .....:
Human   109 SPYALNQEADVSGGYPQCAPAVYSGNLSSPMVQHHH--------------HHQGYA---GGAVGS 156

  Fly   153 PAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDT 217
            |..|....|...:|...::.|.|   .||..|...|          ..:||      ||::|
Human   157 PQYIHHSYGQEHQSLALATYNNS---LSPLHASHQE----------ACRSP------ASETS--- 199

  Fly   218 PLDALFQLSTKNFDEEQDPA-TLNIFATRSNPKKKRK------------SRTAFTNQQIFELEKR 269
                             .|| |.:....:.||.|..|            .||.||.:|:.||||.
Human   200 -----------------SPAQTFDWMKVKRNPPKTGKVGEYGYLGQPNAVRTNFTTKQLTELEKE 247

  Fly   270 FLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAK-LKRDMEELKKDVQCEKIPDQSADP 329
            |.:.|||:.|.|.|||..|.|:..||..||||||.| .||:.|.|        :|...|.|
Human   248 FHFNKYLTRARRVEIAASLQLNETQVKIWFQNRRMKQKKREKEGL--------LPISPATP 300

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	46/138 (33%)
		Homeodomain	252..308	CDD:459649	30/68 (44%)
HOXA1	NP_005513.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	61..80
		Interaction with OGT. /evidence=ECO:0000250|UniProtKB:P09022	75..203		29/149 (19%)
		COG5576	176..>286	CDD:227863	47/148 (32%)
		Antp-type hexapeptide	204..209		1/4 (25%)
		Homeodomain	233..286	CDD:459649	29/52 (56%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	281..335		9/28 (32%)