Protein Alignment lbl and HMX1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_061815.2
• Gene: HMX1 / 3166
• HGNCID: 5017
• Length: 348
• Species: Homo sapiens
• Alignment Length: 313
• Identity: 74/313 - (23%)
• Similarity: 101/313 - (32%)
• Gaps: 108/313 - (34%)

  Fly    46 KSSPVRVKSFSIADIL------------GRGHEEDRVE--KKPE---------------RIAIPN 81
            :::|.|..||.|.::|            |.|..||..|  ..||               |..:..
Human    10 RATPARASSFLIENLLAAEAKGAGRATQGDGSREDEEEDDDDPEDEDAEQARRRRLQRRRQLLAG 74

  Fly    82 ALPGVPAPLALINERLQIPLVPNC------PPPAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQ 140
            ..||..|       |.:..|.|..      |||..     .|...........| |.|   .|..
Human    75 TGPGGEA-------RARALLGPGALGLGPRPPPGP-----GPPFALGCGGAARW-YPR---AHGG 123

  Fly   141 AQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSP-------TQAEKVEKRSQ------ 192
            ....|            |.|.|...|..:....|..|...|       .|.|..|..::
Human   124 YGGGL------------SPDTSDRDSPETGEEMGRAEGAWPRGPGPGAVQREAAELAARGPAAGT 176

  Fly   193 EDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTA 257
            |:..|:     .|.|..|.::.|...:..                           .:|:|:||.
Human   177 EEASEL-----AEVPAAAGETRGGVGVGG---------------------------GRKKKTRTV 209

  Fly   258 FTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDM 310
            |:..|:|:||..|..::|||.|:|..:|..|.|:..||..||||||.|.||.:
Human   210 FSRSQVFQLESTFDLKRYLSSAERAGLAASLQLTETQVKIWFQNRRNKWKRQL 262

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	32/105 (30%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
HMX1	NP_061815.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	29..203		39/233 (17%)
		Homeodomain	206..260	CDD:459649	25/53 (47%)
		HMX family specific domain 1	263..273		74/313 (24%)
		HMX family specific domain 2	276..289