Protein Alignment lbl and HLX

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_068777.1
• Gene: HLX / 3142
• HGNCID: 4978
• Length: 488
• Species: Homo sapiens
• Alignment Length: 336
• Identity: 99/336 - (29%)
• Similarity: 128/336 - (38%)
• Gaps: 81/336 - (24%)

  Fly    49 PVRVK--SFSIADILGRGHEEDRVEKKPERIAIPNALP-----GVPAPLALINERLQIPLVPN-- 104
            |..||  ||.|||||..|..:  :...||.:|..:|..     |...|.|......:.||.|.
Human    36 PAAVKKPSFCIADILHAGVGD--LGAAPEGLAGASAAALTAHLGSVHPHASFQAAARSPLRPTPV 98

  Fly   105 -CPP--PAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERS 166
             .|.  ||.....||| |..:|........|:|.|...|......|...|.|      ..|..|.
Human    99 VAPSEVPAGFPQRLSP-LSAAYHHHHPQQQQQQQQPQQQQPPPPPRAGALQP------PASGTRV 156

  Fly   167 QRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKG---------ASKSSGDTP---- 218
            ..:...:||    :|..:.| :.:...||:    .|.|..||.         .|..:|..|
Human   157 VPNPHHSGS----APAPSSK-DLKFGIDRI----LSAEFDPKVKEGNTLRDLTSLLTGGRPAGVH 212

  Fly   219 LDALFQLSTKNFDEEQDP---ATLNIFATRSNP----------------------------KKKR 252
            |..| |.|...|....||   |:..:....|||                            |:||
Human   213 LSGL-QPSAGQFFASLDPINEASAILSPLNSNPRNSVQHQFQDTFPGPYAVLTKDTMPQTYKRKR 276

  Fly   253 K-SRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKD 316
            . ||..|:|.|...|||||..|||::..||.::|..|||::|||..||||||.|.:.     .|:
Human   277 SWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH-----SKE 336

  Fly   317 VQCEKIPDQSA 327
            .|.:|..|:.|
Human   337 AQAQKDKDKEA 347

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	53/167 (32%)
		Homeodomain	252..308	CDD:459649	30/56 (54%)
HLX	NP_068777.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	118..173		14/65 (22%)
		Homeodomain	273..333	CDD:459649	32/59 (54%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	331..488		5/22 (23%)