DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbl and HHEX

DIOPT Version :10

Sequence 1:NP_001262805.1 Gene:lbl / 42541 FlyBaseID:FBgn0008651 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_002720.1 Gene:HHEX / 3087 HGNCID:4901 Length:270 Species:Homo sapiens


Alignment Length:398 Identity:92/398 - (23%)
Similarity:120/398 - (30%) Gaps:176/398 - (44%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PSPANSDVSVGSPSPPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIADILGRGHEEDRV 70
            |.||...|.|...:|.||                       ..|.....|.|.||||||.     
Human     6 PGPAAGAVGVPLYAPTPL-----------------------LQPAHPTPFYIEDILGRGP----- 42

  Fly    71 EKKPERIAIPNALPGVPAPLALINERLQIPLVPNCPP---PAALHTFLSPALLHSYEQRLA---- 128
                   |.|...|.:|:|    |......:.|...|   |..:|    ||..|.....||    
Human    43 -------AAPTPAPTLPSP----NSSFTSLVSPYRTPVYEPTPIH----PAFSHHSAAALAAAYG 92

  Fly   129 --------WDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAE 185
                    :.:.|.:.::..|   |||...|...::.|.                          
Human    93 PGGFGGPLYPFPRTVNDYTHA---LLRHDPLGKPLLWSP-------------------------- 128

  Fly   186 KVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKK 250
                                                                    |..|  |..
Human   129 --------------------------------------------------------FLQR--PLH 135

  Fly   251 KRK-SRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAK---LKRDME 311
            ||| .:..|:|.|..||||:|..||||||.:|..:|..|.||..||.|||||||||   ||::..
Human   136 KRKGGQVRFSNDQTIELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENP 200

  Fly   312 ELKKDVQCEKIPDQSADPNRSHHNHPHYHQQHQHYAHMQSIGSDRDMDKDRC-----------RE 365
            :..|..:.|.: |.|.|             |.|.....|:.|:  .:|..:|           .|
Human   201 QSNKKEELESL-DSSCD-------------QRQDLPSEQNKGA--SLDSSQCSPSPASQEDLESE 249

  Fly   366 KEKDKDKE 373
            ..:|.|:|
Human   250 ISEDSDQE 257

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lblNP_001262805.1 COG5576 206..332 CDD:227863 43/129 (33%)
Homeodomain 252..308 CDD:459649 33/59 (56%)
HHEXNP_002720.1 Interaction with SOX13. /evidence=ECO:0000269|PubMed:20028982 1..137 42/260 (16%)
Homeodomain 136..194 CDD:459649 33/57 (58%)
Required for WNT signaling induction. /evidence=ECO:0000269|PubMed:20028982 137..270 49/137 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 194..270 17/80 (21%)

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