Protein Alignment lbl and Npm1

DIOPT Version :9

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_037124.1
• Gene: Npm1 / 25498
• RGDID: 3192
• Length: 292
• Species: Rattus norvegicus
• Alignment Length: 265
• Identity: 50/265 - (18%)
• Similarity: 88/265 - (33%)
• Gaps: 74/265 - (27%)

  Fly    85 GVPAPLALINERLQI-PLVP----NCPPPAALHTFLSPALLHSYEQRL-AWDYQRQLQEHFQAQA 143
            |.|..:.|...::.: |.|.    ...||..|........:|...|.| |.:...:.::..:...
  Rat    69 GSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDV 133

  Fly   144 QLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQE--------------- 193
            :||              |.|  .:||:...|:.   .|.:..|:::...|
  Rat   134 KLL--------------GMS--GKRSAPGGGNK---VPQKKVKLDEDDDEDDEDDEDDEDDDDDD 179

  Fly   194 -DRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTA 257
             |..|..:|.|      ..||..|||.... |.|.:| .::..|:|.......|..|:::..:|.
  Rat   180 FDEEETEEKVP------VKKSVRDTPAKNA-QKSNQN-GKDLKPSTPRSKGQESFKKQEKTPKTP 236

  Fly   258 FTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKI 322
            .....:.:::.:.  |..:      |..|.|....|:.|.:.:|                 |.::
  Rat   237 KGPSSVEDIKAKM--QASI------EKGGSLPKVEAKFINYVKN-----------------CFRM 276

  Fly   323 PDQSA 327
            .||.|
  Rat   277 TDQEA 281

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	24/122 (20%)
		Homeobox	254..307	CDD:278475	8/52 (15%)
Npm1	NP_037124.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..185		23/134 (17%)
		Necessary for interaction with APEX1. /evidence=ECO:0000250	1..117		10/47 (21%)
		Nucleoplasmin	18..117	CDD:397268	10/47 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	138..248		24/122 (20%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	190..196		3/11 (27%)
		Required for nucleolar localization. /evidence=ECO:0000250	241..292		11/66 (17%)
		NPM1-C	243..289	CDD:406641	11/64 (17%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900