Protein Alignment lbl and Nkx2-4

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_075993.1
• Gene: Nkx2-4 / 228731
• MGIID: 97349
• Length: 354
• Species: Mus musculus
• Alignment Length: 296
• Identity: 72/296 - (24%)
• Similarity: 109/296 - (36%)
• Gaps: 81/296 - (27%)

  Fly    48 SPVRVKSFSIADILGRGHEEDRVEKKPERI--AIPNALPGVPAPLALINERLQIPLVPNCP---- 106
            ||.....||::|||      ..:|:..::.  .:..|.||:.|||.....|..    |:.|
Mouse     4 SPKHTTPFSVSDIL------SPIEETYKKFGGVMDGAPPGLGAPLGAAAYRAP----PSGPSSQA 58

  Fly   107 --------PPAAL--HTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDG 161
                    ||.|:  |...:.|...:.....|..|.                  :.|.:
Mouse    59 AAVAAGMQPPHAMAGHNAAAAAAAAAAAAAAAATYH------------------MPPGV------ 99

  Fly   162 SSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRME---------------VPKKSPEEQPKGAS 211
                ||...|:.||  .|:.......|..:..|.|.               .|:.|...:..|.|
Mouse   100 ----SQFPHSAMGS--YCNGGLGNMGELPAYTDGMRGGAAAAATGWYGANTDPRYSSISRFMGPS 158

  Fly   212 KSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYL 276
            .......:.:|..::    |..:..|.|:..|.|      ||.|..|:..|::|||:||..||||
Mouse   159 AGVNVAGMGSLTGIA----DAAKSLAPLHAAAPR------RKRRVLFSQAQVYELERRFKQQKYL 213

  Fly   277 SPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEE 312
            |..:|:.:|..:.|:..||..||||.|.|:||..::
Mouse   214 SAPEREHLASMIHLTPTQVKIWFQNHRYKMKRQAKD 249

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	36/107 (34%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
Nkx2-4	NP_075993.1	Homeodomain	189..245	CDD:459649	26/55 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	245..329		1/5 (20%)