Protein Alignment lbl and EN1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001417.3
• Gene: EN1 / 2019
• HGNCID: 3342
• Length: 392
• Species: Homo sapiens
• Alignment Length: 407
• Identity: 84/407 - (20%)
• Similarity: 135/407 - (33%)
• Gaps: 146/407 - (35%)

  Fly     1 MPQRTPSP-ANSDVSVGSPSPPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIADILGRG 64
            |.::.|.| :..|.::|:.:......|:          :||......||             |.|
Human     1 MEEQQPEPKSQRDSALGAAAAATPGGLS----------LSLSPGASGSS-------------GSG 42

  Fly    65 HEEDRVEKKPERIAIPNALPGVPAPLALINERLQIPLVPNCPPPAALHTFLSPALLHSYEQRLAW 129
            .:.|.|...|:        |..|:|          |..| |.||.|.|..|.|.......|.||.
Human    43 SDGDSVPVSPQ--------PAPPSP----------PAAP-CLPPLAHHPHLPPHPPPPPPQHLAA 88

  Fly   130 D-YQRQ----------------LQEHF-----QAQAQLL------------------RQMT---- 150
            . :|.|                |:..|     |...|||                  |..|
Human    89 PAHQPQPAAQLHRTTNFFIDNILRPDFGCKKEQPPPQLLVAAAARGGAGGGGRVERDRGQTAAGR 153

  Fly   151 --LNP---------AIIASED---GSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKK 201
              ::|         :::.:.|   |..:.||.:::..|:::..:|..|......:..........
Human   154 DPVHPLGTRAPGAASLLCAPDANCGPPDGSQPAAAGAGASKAGNPAAAAAAAAAAVAAAAAAAAA 218

  Fly   202 SPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLN-----------------------IFA 243
            .|.:...|.|.....:|    ....|| :.|..:||.|.                       ::.
Human   219 KPSDTGGGGSGGGAGSP----GAQGTK-YPEHGNPAILLMGSANGGPVVKTDSQQPLVWPAWVYC 278

  Fly   244 TR-----------------SNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLS 291
            ||                 .|.|:.::.|||||.:|:..|:..|...:|::...|..:|..|.|:
Human   279 TRYSDRPSSGPRTRKLKKKKNEKEDKRPRTAFTAEQLQRLKAEFQANRYITEQRRQTLAQELSLN 343

  Fly   292 NAQVITWFQNRRAKLKR 308
            .:|:..||||:|||:|:
Human   344 ESQIKIWFQNKRAKIKK 360

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	35/143 (24%)
		Homeodomain	252..308	CDD:459649	21/55 (38%)
EN1	NP_001417.3	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..100		32/140 (23%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	132..164		3/31 (10%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	219..251		9/36 (25%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	282..306		2/23 (9%)
		Homeodomain	305..360	CDD:459649	21/54 (39%)
		Engrail_1_C_sig	361..391	CDD:431338	84/407 (21%)