Protein Alignment lbl and EMX2

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_004089.1
• Gene: EMX2 / 2018
• HGNCID: 3341
• Length: 252
• Species: Homo sapiens
• Alignment Length: 354
• Identity: 76/354 - (21%)
• Similarity: 103/354 - (29%)
• Gaps: 166/354 - (46%)

  Fly    20 PPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIAD-----------------ILGRGHEE 67
            |.|.|...::.|....||:...   :...|:|..:.|.|:                 ..|||
Human     4 PAPKRCFTIESLVAKDSPLPAS---RSEDPIRPAALSYANSSPINPFLNGFHSAAAAAAGRG--- 62

  Fly    68 DRVEKKPERIAIPNALPGVPAPLALINERLQIPLVPNCPPPAAL--------HT----FLS---- 116
              |...|: :....|:...|.|        .:|:.| .|||.||        |:    |.|
Human    63 --VYSNPD-LVFAEAVSHPPNP--------AVPVHP-VPPPHALAAHPLPSSHSPHPLFASQQRD 115

  Fly   117 -----PALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGST 176
                 |.|:|.|         |.|...||..
Human   116 PSTFYPWLIHRY---------RYLGHRFQGN---------------------------------- 137

  Fly   177 ECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNI 241
                                   ..|||.                 |.|.             |.
Human   138 -----------------------DTSPES-----------------FLLH-------------NA 149

  Fly   242 FATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKL 306
            .|     :|.::.||||:..|:..||..|....|:..|:|.::|..|.|:..||..||||||.|.
Human   150 LA-----RKPKRIRTAFSPSQLLRLEHAFEKNHYVVGAERKQLAHSLSLTETQVKVWFQNRRTKF 209

  Fly   307 KRD-MEELKKDVQCEKIPDQSADPNRSHH 334
            ||. :||...|.|.:|        ..:||
Human   210 KRQKLEEEGSDSQQKK--------KGTHH 230

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	35/126 (28%)
		Homeodomain	252..308	CDD:459649	23/55 (42%)
EMX2	NP_004089.1	Homeodomain	155..211	CDD:459649	23/55 (42%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	212..252		7/27 (26%)