Protein Alignment lbl and Pdx1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_032840.1
• Gene: Pdx1 / 18609
• MGIID: 102851
• Length: 284
• Species: Mus musculus
• Alignment Length: 229
• Identity: 61/229 - (26%)
• Similarity: 89/229 - (38%)
• Gaps: 72/229 - (31%)

  Fly   136 QEHFQAQAQLLR-----------QMTLNP--AIIASEDGSSERSQRSSSSNGSTECCSPTQAEKV 187
            :|.:.|..||.:           :.:.||  .:............:.:||.||.|..||
Mouse     4 EEQYYAATQLYKDPCAFQRGPVPEFSANPPACLYMGRQPPPPPPPQFTSSLGSLEQGSP------ 62

  Fly   188 EKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALF------QLSTKN-----FDEEQDPATLN- 240
                       |..||.|.|..||    |.|..|..      ||...:     |....:|..|.
Mouse    63 -----------PDISPYEVPPLAS----DDPAGAHLHHHLPAQLGLAHPPPGPFPNGTEPGGLEE 112

  Fly   241 ----------IFATRSN--------------PKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADR 281
                      :.:|:::              |::.:::|||:|..|:.||||.||:.||:|...|
Mouse   113 PNRVQLPFPWMKSTKAHAWKGQWAGGAYTAEPEENKRTRTAYTRAQLLELEKEFLFNKYISRPRR 177

  Fly   282 DEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKK 315
            .|:|..|.|:...:..||||||.|.|:  ||.||
Mouse   178 VELAVMLNLTERHIKIWFQNRRMKWKK--EEDKK 209

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	44/146 (30%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
Pdx1	NP_032840.1	Transactivation domain. /evidence=ECO:0000250	13..73		15/76 (20%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	30..116		24/106 (23%)
		Antp-type hexapeptide	119..124		0/4 (0%)
		Homeodomain	148..204	CDD:459649	26/55 (47%)
		Nuclear localization signal	198..204		3/5 (60%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	202..284		5/10 (50%)