DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbl and Npm1

DIOPT Version :9

Sequence 1:	NP_001262805.1	Gene:	lbl / 42541	FlyBaseID:	FBgn0008651	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_032748.1	Gene:	Npm1 / 18148	MGIID:	106184	Length:	292	Species:	Mus musculus

Alignment Length:	265	Identity:	49/265 - (18%)
Similarity:	89/265 - (33%)	Gaps:	74/265 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    85 GVPAPLALINERLQI-PLVP----NCPPPAALHTFLSPALLHSYEQRL-AWDYQRQLQEHFQAQA 143
            |.|..:.|...::.: |.|.    ...||..|........:|...|.| |.:...:.::..:...
Mouse    69 GSPIKVTLATLKMSVQPTVSLGGFEITPPVVLRLKCGSGPVHISGQHLVAVEEDAESEDEDEEDV 133

  Fly   144 QLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQE--------------- 193
            :||              |.|  .:||:...|:.   .|.:..|:::..::
Mouse   134 KLL--------------GMS--GKRSAPGGGNK---VPQKKVKLDEDDEDDDEDDEDDEDDDDDD 179

  Fly   194 -DRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTA 257
             |..|..:|.|      ..||..|||.... |.|.:| .::..|:|.......|..|:::..:|.
Mouse   180 FDEEETEEKVP------VKKSVRDTPAKNA-QKSNQN-GKDLKPSTPRSKGQESFKKQEKTPKTP 236

  Fly   258 FTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKI 322
            .....:.:::.:.  |..:      |..|.|....|:.|.:.:|                 |.::
Mouse   237 KGPSSVEDIKAKM--QASI------EKGGSLPKVEAKFINYVKN-----------------CFRM 276

  Fly   323 PDQSA 327
            .||.|
Mouse   277 TDQEA 281

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	24/122 (20%)
lbl	NP_001262805.1	Homeobox	254..307	CDD:278475	8/52 (15%)
Npm1	NP_032748.1	Required for interaction with SENP3. /evidence=ECO:0000250	1..185		22/134 (16%)
		Necessary for interaction with APEX1. /evidence=ECO:0000250	1..117		10/47 (21%)
		Nucleoplasmin	18..116	CDD:308605	10/46 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	138..248		23/122 (19%)
		Nuclear localization signal. /evidence=ECO:0000255	152..157		1/4 (25%)
		Nuclear localization signal. /evidence=ECO:0000255	190..196		3/11 (27%)
		Required for nucleolar localization. /evidence=ECO:0000250	241..292		11/66 (17%)
		NPM1-C	243..291	CDD:318505	11/64 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0488
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900