Protein Alignment lbl and Nkx6-1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_659204.1
• Gene: Nkx6-1 / 18096
• MGIID: 1206039
• Length: 365
• Species: Mus musculus
• Alignment Length: 442
• Identity: 90/442 - (20%)
• Similarity: 140/442 - (31%)
• Gaps: 179/442 - (40%)

  Fly     1 MPQRTPSPANSDVSVGSPSPPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIADILGRGH 65
            :|...||.::|..|..||| |||.|.|                     |..:|..:...:...|
Mouse    43 LPTGPPSSSSSSSSSSSPS-PPLGSHN---------------------PGGLKPPAAGGLSSLG- 84

  Fly    66 EEDRVEKKPERI--AIPNALPGVPAPLALINERLQIPLVPNCPPPAALHTFLSPALLHSYEQRLA 128
                  ..|:::  |.|:.          ||:.|..|.:|          ..|.|.|.|
Mouse    85 ------SPPQQLSAATPHG----------INDILSRPSMP----------VASGAALPS------ 117

  Fly   129 WDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEKVEKRSQE 193
                                        ||..|||..|..|:|:..::...:...|......|..
Mouse   118 ----------------------------ASPSGSSSSSSSSASATSASAAAAAAAAAAAAAASSP 154

  Fly   194 ----------DRMEVPKKSP--------------EEQPKGASKSSGDTPL------------DAL 222
                      ..:..|...|              ...||..::..|.||:            ||.
Mouse   155 AGLLAGLPRFSSLSPPPPPPGLYFSPSAAAVAAVGRYPKPLAELPGRTPIFWPGVMQSPPWRDAR 219

  Fly   223 FQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGG 287
            ...:         |...:|...:..  |::.:|..|:.||||.|||.|...|||:..:|..:|..
Mouse   220 LACT---------PHQGSILLDKDG--KRKHTRPTFSGQQIFALEKTFEQTKYLAGPERARLAYS 273

  Fly   288 LGLSNAQVITWFQNRRAKLKRDMEELKKDVQCEKIPDQSADPNRSHHNHPHYHQQHQHYAHMQSI 352
            ||::.:||..||||||.|.::                                   :|.|.|.:.
Mouse   274 LGMTESQVKVWFQNRRTKWRK-----------------------------------KHAAEMATA 303

  Fly   353 GSDRDMDKDRCR---EKEKDKD---------KEELRMLKLMTLMRYSDGKLL 392
            ...:|.:.:|.:   |.|:|.|         .::.::.:|:...:.|.|.||
Mouse   304 KKKQDSETERLKGTSENEEDDDDYNKPLDPNSDDEKITQLLKKHKSSGGSLL 355

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	36/137 (26%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
Nkx6-1	NP_659204.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	35..136		36/175 (21%)
		Repressor domain. /evidence=ECO:0000250	102..269		43/221 (19%)
		Homeodomain	236..294	CDD:459649	27/57 (47%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	295..365		14/61 (23%)
		Involved in DNA-binding. /evidence=ECO:0000250	307..365		11/49 (22%)