DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbl and Hlx

DIOPT Version :9

Sequence 1:NP_001262805.1 Gene:lbl / 42541 FlyBaseID:FBgn0008651 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_032276.1 Gene:Hlx / 15284 MGIID:96109 Length:476 Species:Mus musculus


Alignment Length:344 Identity:92/344 - (26%)
Similarity:124/344 - (36%) Gaps:100/344 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    49 PVRVK--SFSIADILGRGHEEDRVEKKPERIAIPNALPGVPAPLALINERLQI-----------P 100
            |..||  ||.|||||..|..    |..|....:..|...:.|.|..::.....           |
Mouse    36 PAAVKKPSFCIADILHAGVG----EPGPAAEGLVGASAALTAHLGSVHPHASFQAAARSPLRPTP 96

  Fly   101 LVPNCPPPAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNP-----AIIASED 160
            :|.....||.....||| |..::.|.|......|.|:..|......|.::|.|     .::....
Mouse    97 VVAPSEVPAGFPQRLSP-LSAAFHQHLPQQSPTQQQQPQQQPPPPPRAVSLQPPTSGTRVVPHHS 160

  Fly   161 GSSERSQRSSSSNGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLD----- 220
            ||                 :|..:.| :.:...||:    .|.|..||   ...|:|..|     
Mouse   161 GS-----------------APAPSSK-DLKFGIDRI----LSAEFDPK---VKEGNTLRDLTSLL 200

  Fly   221 ----------ALFQLSTKNFDEEQDP---ATLNIFATRSNP------------------------ 248
                      |..|.|...|....||   |:..:....|||                        
Mouse   201 TGGRPAGVHLAGLQPSAGQFFASLDPISEASAILSPLSSNPRNSVQHQFQDTFPGPYAVLTKDTM 265

  Fly   249 ----KKKRK-SRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKR 308
                |:||. ||..|:|.|...|||||..|||::..||.::|..|||::|||..||||||.|.:.
Mouse   266 PQTYKRKRSWSRAVFSNLQRKGLEKRFEIQKYVTKPDRKQLAAMLGLTDAQVKVWFQNRRMKWRH 330

  Fly   309 DMEELKKDVQCEKIPDQSA 327
                 .|:.|.:|..|:.|
Mouse   331 -----SKEAQAQKDKDKEA 344

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lblNP_001262805.1 COG5576 206..332 CDD:227863 52/169 (31%)
Homeobox 254..307 CDD:278475 29/52 (56%)
HlxNP_032276.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 120..169 11/65 (17%)
COG5576 224..>341 CDD:227863 41/121 (34%)
Homeobox 276..329 CDD:278475 29/52 (56%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 328..401 5/22 (23%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 413..476
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0488
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.810

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