DRSC/TRiP Functional Genomics Resources

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Protein Alignment lbl and Hhex

DIOPT Version :10

Sequence 1:NP_001262805.1 Gene:lbl / 42541 FlyBaseID:FBgn0008651 Length:410 Species:Drosophila melanogaster
Sequence 2:NP_032271.1 Gene:Hhex / 15242 MGIID:96086 Length:271 Species:Mus musculus


Alignment Length:396 Identity:89/396 - (22%)
Similarity:120/396 - (30%) Gaps:179/396 - (45%)


- Green bases have known domain annotations that are detailed below.


  Fly     6 PSPANSDVSVGSP--SPPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIADILGRGHEED 68
            |.||.:. :||.|  :|.||                       ..|.....|.|.||||||.   
Mouse     6 PGPAAAP-AVGVPLYAPTPL-----------------------LQPAHPTPFYIDDILGRGP--- 43

  Fly    69 RVEKKPERIAIPNALPGVPAPLALINERLQIPLVPNCPPPAALHTFLSPALLHSYEQRLA----- 128
                     |.|...|.:|:|.:....     ||.:...|....|.:.||..|.....||     
Mouse    44 ---------AAPTPTPTLPSPNSSFTS-----LVSSYRTPVYEPTPVHPAFSHHPAAALAAAYGP 94

  Fly   129 -------WDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSPTQAEK 186
                   :.:.|.:.::..|   |||...|...::.|.                           
Mouse    95 SGFGGPLYPFPRTVNDYTHA---LLRHDPLGKPLLWSP--------------------------- 129

  Fly   187 VEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRSNPKKK 251
                                                                   |..|  |..|
Mouse   130 -------------------------------------------------------FLQR--PLHK 137

  Fly   252 RK-SRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRDMEE--- 312
            || .:..|:|.|..||||:|..||||||.:|..:|..|.||..||.|||||||||.:|..:|   
Mouse   138 RKGGQVRFSNDQTVELEKKFETQKYLSPPERKRLAKMLQLSERQVKTWFQNRRAKWRRLKQENPQ 202

  Fly   313 -LKK------DVQCEKIPDQSADPNRSHHNHPHYHQQHQHYAHMQSIGSDRDMDKDRCR---EKE 367
             .||      |..||:..|..::.|:.                       ..:|:.:|.   ..:
Mouse   203 SNKKDALDSLDTSCEQGQDLPSEQNKG-----------------------ASLDRSQCSPSPASQ 244

  Fly   368 KDKDKE 373
            :|.|.|
Mouse   245 EDPDSE 250

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
lblNP_001262805.1 COG5576 206..332 CDD:227863 45/136 (33%)
Homeodomain 252..308 CDD:459649 32/56 (57%)
HhexNP_032271.1 Interaction with SOX13. /evidence=ECO:0000250|UniProtKB:Q03014 1..138 42/259 (16%)
Required for WNT signaling induction. /evidence=ECO:0000250|UniProtKB:Q03014 138..271 46/136 (34%)
Homeodomain 143..195 CDD:459649 30/51 (59%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 195..271 14/79 (18%)

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