Protein Alignment lbl and DBX1

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_001025036.2
• Gene: DBX1 / 120237
• HGNCID: 33185
• Length: 343
• Species: Homo sapiens
• Alignment Length: 435
• Identity: 96/435 - (22%)
• Similarity: 131/435 - (30%)
• Gaps: 181/435 - (41%)

  Fly    16 GSPS---PPPLRSLNMKRLRLLRSPISLEHDRQKSSPVRVKSFSIADILGRGHEEDRVEKKPERI 77
            |.||   |.|..:|          |.||:......|     ||.:.|::       |:.:.|..:
Human    12 GYPSLLRPTPTLTL----------PQSLQSAFSGHS-----SFLVEDLI-------RISRPPAYL 54

  Fly    78 --AIPNALPGVP---APLALI-------------NERLQIPLVPNCPPPAALHTFL--------- 115
              ::|.|....|   ||.||.             :.|...|  |....||:..|||
Human    55 PRSVPTASMSPPRQGAPTALTDTGASDLGSPGPGSRRGGSP--PTAFSPASETTFLKFGVNAILS 117

  Fly   116 -------SPALLHSYEQR-LAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSS 172
                   |||||.|...: .|:.|       |:...|...:.:..||
Human   118 SGPRTETSPALLQSVPPKTFAFPY-------FEGSFQPFIRSSYFPA------------------ 157

  Fly   173 NGSTECCSPTQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPA 237
                                                    ||...|:...|...
Human   158 ----------------------------------------SSSVVPIPGTFSWP----------- 171

  Fly   238 TLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNR 302
                .|.|..|::....|..|::.|...|||.|..|||:|..||.::|..|||.::||..|||||
Human   172 ----LAARGKPRRGMLRRAVFSDVQRKALEKMFQKQKYISKPDRKKLAAKLGLKDSQVKIWFQNR 232

  Fly   303 RAKLKRDME-ELKKDVQCEK---------IPD-----QSADPNRSHHNHP---------HYHQQH 343
            |.|.:...| ||.....|.:         .||     |....|......|         |.....
Human   233 RMKWRNSKERELLSSGGCREQTLPTKLNPHPDLSDVGQKGPGNEEEEEGPGSPSHRLAYHASSDP 297

  Fly   344 QHY-------------AHMQSIGSDRDMDKDRCREKEKDKDKEEL 375
            ||.             ||..|.|...|....  .|:|:.:::||:
Human   298 QHLRDPRLPGPLPPSPAHSSSPGKPSDFSDS--EEEEEGEEQEEI 340

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	41/140 (29%)
		Homeodomain	252..308	CDD:459649	26/55 (47%)
DBX1	NP_001025036.2	PRK12323	<49..182	CDD:481241	35/214 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	56..100		10/45 (22%)
		Homeodomain	184..238	CDD:459649	26/53 (49%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	240..343		21/103 (20%)