Protein Alignment lbl and Nkx2-5

DIOPT Version :10

• Sequence 1: NP_001262805.1
• Gene: lbl / 42541
• FlyBaseID: FBgn0008651
• Length: 410
• Species: Drosophila melanogaster
• Sequence 2: NP_446103.2
• Gene: Nkx2-5 / 114109
• RGDID: 620520
• Length: 319
• Species: Rattus norvegicus
• Alignment Length: 224
• Identity: 69/224 - (30%)
• Similarity: 99/224 - (44%)
• Gaps: 45/224 - (20%)

  Fly   106 PPPAALHTFLSPALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAII-------------- 156
            |.||..||..|...:.:.||:     ||.|... ...|:|  :.||.||..
  Rat     3 PSPALTHTPFSVKDILNLEQQ-----QRSLAAG-DLSARL--EATLAPASCMLAAFKPEAYSGPE 59

  Fly   157 ASEDGSSE-RSQRSSSSNGSTECCSPT--QAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTP 218
            |:..|.:| |::...:.  |...|||.  .|.....|:..|      ..|.:.|:...|.
  Rat    60 AAAPGLAELRAELGPAP--SPPKCSPAFPTAPTFYPRAYGD------PDPAKDPRADKKE----- 111

  Fly   219 LDALFQLSTKNFDEEQDPATLNIFATRSNPKKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDE 283
            |.|| |.:.:....|.|.      |.|...:::||.|..|:..|::|||:||..|:|||..:||:
  Rat   112 LCAL-QKAVELDKAETDG------AERPRARRRRKPRVLFSQAQVYELERRFKQQRYLSAPERDQ 169

  Fly   284 IAGGLGLSNAQVITWFQNRRAKLKRDMEE 312
            :|..|.|::.||..||||||.|.||..::
  Rat   170 LASVLKLTSTQVKIWFQNRRYKCKRQRQD 198

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	40/107 (37%)
		Homeodomain	252..308	CDD:459649	28/55 (51%)
Nkx2-5	NP_446103.2	Homeodomain	144..194	CDD:459649	25/49 (51%)