DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment lbl and hoxa3

DIOPT Version :9

Sequence 1:	NP_001262805.1	Gene:	lbl / 42541	FlyBaseID:	FBgn0008651	Length:	410	Species:	Drosophila melanogaster
Sequence 2:	NP_001120901.1	Gene:	hoxa3 / 100151729	XenbaseID:	XB-GENE-482267	Length:	406	Species:	Xenopus tropicalis

Alignment Length:	262	Identity:	64/262 - (24%)
Similarity:	97/262 - (37%)	Gaps:	97/262 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    70 VEKKPERIAIPNALPGVPAP-----------LALINERL-QIPLV------PNCPPPAALHTFLS 116
            :|.:..|.|.....||...|           :..||.:. |.|::      |..|||:     :|
Frog    40 LETEYHRPACSLQSPGSAVPHHKANDINESCMRTINSQSNQAPVIPEQQPTPQGPPPS-----VS 99

  Fly   117 PALLHSYEQRLAWDYQRQLQEHFQAQAQLLRQMTLNPAIIASEDGSSERSQRSSSSNGSTECCSP 181
            |.                             |.|.|.|              ::|||.:|...||
Frog   100 PP-----------------------------QTTSNAA--------------TASSNKATSITSP 121

  Fly   182 TQAEKVEKRSQEDRMEVPKKSPEEQPKGASKSSGDTPLDALFQLSTKNFDEEQDPATLNIFATRS 246
            |.::::....:|.|...      :|.|..|.|||:                       :....:|
Frog   122 TMSKQIFPWMKESRQNT------KQQKAGSSSSGE-----------------------SCAGDKS 157

  Fly   247 NP--KKKRKSRTAFTNQQIFELEKRFLYQKYLSPADRDEIAGGLGLSNAQVITWFQNRRAKLKRD 309
            .|  ...:::|||:|:.|:.||||.|.:.:||....|.|:|..|.|:..|:..||||||.|.|:|
Frog   158 PPGQSSSKRARTAYTSAQLVELEKEFHFNRYLCRPRRVEMANLLNLTERQIKIWFQNRRMKYKKD 222

  Fly   310 ME 311
            .:
Frog   223 QK 224

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
lbl	NP_001262805.1	COG5576	206..332	CDD:227863	35/108 (32%)
lbl	NP_001262805.1	Homeobox	254..307	CDD:278475	25/52 (48%)
hoxa3	NP_001120901.1	Homeobox	168..221	CDD:395001	25/52 (48%)
hoxa3	NP_001120901.1	DUF4074	344..404	CDD:404218
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910