DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and Ugt1a6a

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_659545.2	Gene:	Ugt1a6a / 94284	MGIID:	2137698	Length:	531	Species:	Mus musculus

Alignment Length:	562	Identity:	150/562 - (26%)
Similarity:	257/562 - (45%)	Gaps:	91/562 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLLGTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITP---------------- 55
            ||:.|..:..|.::|.   :|.. ||::....|:..|.:|||::..:.|
Mouse    16 LFLVLWASVLGDKLLV---VPQDGSHWLSMKEIVEHLSERGHDIMVLVPEVNLLLGESKYYRRKI 77

  Fly    56 --LSLAKENLGPNYREI----LLPKYDTWADISAMMKTKSALDMI---------DMSKLTHMRLA 105
              ::.:.|.|...:|..    .||.......:.........:||.         |.:.|:.:|
Mouse    78 FSVTYSLEELQTRFRTFGNNHFLPGASLMGPLREYRNNMIVVDMFFSNCQSLLKDSATLSFLR-- 140

  Fly   106 QHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIATFAYANY 170
                                      :.|||.|..:.....|.::..|: .:|::    :.:..:
Mouse   141 --------------------------ENKFDALFTDPAMPCGVILAEYL-NLPSV----YLFRGF 174

  Fly   171 ---FSQVFG-FVNPLSYVPNVFLSCTDRMSLWERLENVVISTAEDVVREVSYYPQQDAVIRKH-- 229
               ...:.| ..:|:||||..:...:|.|:..:||.|.:::..|:.:    ||    .:..|:
Mouse   175 PCSLEHMLGQSPSPVSYVPRFYTKFSDHMTFPQRLANFIVNILENYL----YY----CLYSKYEI 231

  Fly   230 -FSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYLD-N 292
             .|.||.|..::..|.|| |:.||........|||:..|||.:||::......|.:..:.|:: :
Mouse   232 IASDLLKRDVSLPSLHQN-SLWLLRYDFVFEYPRPVMPNMIFLGGINCKKKGKLTQEFEAYVNAS 295

  Fly   293 AEHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQADI 357
            .|||.:.|||||.|  :::|.:|.....:....:.|.|||::...:..||..|..:.|||||.|:
Mouse   296 GEHGIVVFSLGSMV--SEIPEKKAMEIAEALGRIPQTVLWRYTGTRPSNLAKNTILVKWLPQNDL 358

  Fly   358 LAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKS 422
            |.||..:.||.|.|..|:.|.:.:.||::.||.:.||..|.|..:..|..:.|:...::.|.|::
Mouse   359 LGHPKTRAFITHSGSHGIYEGICNGVPMVMMPLFGDQMDNAKRMETRGAGVTLNVLEMTADDLEN 423

  Fly   423 ALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFYLLD 487
            ||..::.:..|:.|:|:.|.:.:|||:..:|.|::|:.||:.|:|||||..|...|.|||::.||
Mouse   424 ALKTVINNKSYKENIMRLSSLHKDRPIEPLDLAVFWVEYVMRHKGAPHLRPAAHDLTWYQYHSLD 488

  Fly   488 VSAIILAITLLPLLTLYAVSRNY---KSFRGIRAQKKEAKTE 526
            |...:|||.|..:..::.... |   |.|.|....||..|::
Mouse   489 VIGFLLAIVLTVVFIVFKCCA-YGCRKCFGGKGRVKKSHKSK 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	143/533 (27%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	136/504 (27%)
Ugt1a6a	NP_659545.2	egt	15..503	CDD:223071	143/533 (27%)
Ugt1a6a	NP_659545.2	UDPGT	27..522	CDD:278624	143/542 (26%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167840806
Domainoid	1	1.000	259	1.000	Domainoid score	I1975
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	272	1.000	Inparanoid score	I2975
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		otm42461
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	10	9.740