DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ATG26

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_013290.1	Gene:	ATG26 / 850886	SGDID:	S000004179	Length:	1198	Species:	Saccharomyces cerevisiae

Alignment Length:	490	Identity:	96/490 - (19%)
Similarity:	163/490 - (33%)	Gaps:	161/490 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    38 AIIRELVKRGHEVTFITP------------------------LSLAKENLGPNYREI--LLPKYD 76
            |:.:.|:|.||:|..||.                        :||..||...|.:.:  ...|:.
Yeast   758 ALGKGLIKEGHQVVIITHSEFRDFVESHGIQFEEIAGNPVELMSLMVENESMNVKMLREASSKFR 822

  Fly    77 TWADISAMMKTKSALDMIDMSKLTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLL-- 139
            .|.|  |:::|.                                      :....:.|||:|:
Yeast   823 GWID--ALLQTS--------------------------------------WEVCNRRKFDILIES 847

  Fly   140 ---VEQFHNEGALMLGYIYEIPAITIATFAYANYF----SQVFGFVNPLSYV--PNVF-LSCTDR 194
               :...|...||.:.|..........|.||.:.|    .:..|..|.|::|  .||| ...:.:
Yeast   848 PSAMVGIHITEALQIPYFRAFTMPWTRTRAYPHAFIVPDQKRGGNYNYLTHVLFENVFWKGISGQ 912

  Fly   195 MSLWERLENVVISTAEDVVREVSYYPQQDAVIRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLT 259
            ::.| |:|.:.:...                             .:..|:||....|.|....:.
Yeast   913 VNKW-RVETLGLGKT-----------------------------NLFLLQQNNVPFLYNVSPTIF 947

  Fly   260 SPRPMSQNMISVGGLHIL-------PPKPLPEHIKNYLDNAEHGAIYFSLGSQV--RSADMPAEK 315
            .|.......:.|.|...|       ||..|.|.|.......:. .:|...||.|  .:.:|....
Yeast   948 PPSIDFSEWVRVTGYWFLDDKSTFKPPAELQEFISEARSKGKK-LVYIGFGSIVVSNAKEMTEAL 1011

  Fly   316 LQIFL--DVFASLKQ--------RVLWKFEDDQLP-------NLPDNVKVEKWL-PQADILAHPN 362
            ::..:  ||:..|.:        :...|.|.| ||       |:|.:     || ||.|...|
Yeast  1012 VEAVMEADVYCILNKGWSERLGDKAAKKTEVD-LPRNILNIGNVPHD-----WLFPQVDAAVH-- 1068

  Fly   363 VKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQLKSAL--- 424
                  |||......::...:|.:..||:.||  ...||:.....:|:..:.::...|..||
Yeast  1069 ------HGGSGTTGASLRAGLPTVIKPFFGDQ--FFYAGRVEDIGVGIALKKLNAQTLADALKVA 1125

  Fly   425 --HALLKDPKYQANMMKASRIFRDRPLGAMDTAMY 457
              :.::||   :|.::| .:|.::..:....:|:|
Yeast  1126 TTNKIMKD---RAGLIK-KKISKEDGIKTAISAIY 1156

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	96/490 (20%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	96/490 (20%)
ATG26	NP_013290.1	GRAM	194..>239	CDD:214725
		PH-GRAM1_AGT26	219..335	CDD:275402
		PH-GRAM2_AGT26	581..673	CDD:275403
		YjiC	739..1168	CDD:224732	96/490 (20%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.698165	Normalized mean entropy	S5056
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.950