DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ugt49B2 and ugt2a4

DIOPT Version :9

Sequence 1:	NP_001097859.4	Gene:	Ugt49B2 / 42538	FlyBaseID:	FBgn0038886	Length:	526	Species:	Drosophila melanogaster
Sequence 2:	NP_001170804.2	Gene:	ugt2a4 / 791613	ZFINID:	ZDB-GENE-080721-23	Length:	533	Species:	Danio rerio

Alignment Length:	562	Identity:	159/562 - (28%)
Similarity:	261/562 - (46%)	Gaps:	82/562 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 LFVCLL----GTGDGARILAPFFLPVK-SHFMMTDAIIRELVKRGHEVTFITPLS---------- 57
            |.||||    ..|...|:|.   :|.: ||:....|||..||.|.|.||.:...|
Zfish     6 LLVCLLLCGVDVGWSGRVLV---MPGEYSHWHNMRAIIEALVDRNHSVTVLVSSSSPTVPHTQKA 67

  Fly    58 -----LAKENLGPNYREILLPKYDTWADISA--MMKTKSALDM-----------------IDMSK 98
                 :.|.|:.....:::      |:|.:.  |.:|.|.|:.                 :..|.
Zfish    68 RFDYHVFKVNMDKEEAKVI------WSDFTHLWMKETDSKLERGFLIWRVMSNFRRLAADVCRSL 126

  Fly    99 LTHMRLAQHIGIKSTDFALAHPEVQELIYAKDKKGKFDLLLVEQFHNEGALMLGYIYEIPAITIA 163
            |.:..|.|.:|....|...:.|    ::...|                   ::.....||.:...
Zfish   127 LQNDDLLQMLGESHYDVLFSDP----MMPCSD-------------------LMAQTLNIPQVISL 168

  Fly   164 TFAYANYFSQVFG-FVNPLSYVPNVFLS--CTDRMSLWERLENVVISTAEDVVREVSYYPQQDAV 225
            ...:|..|.::.| ...|.||||.|.|:  .|||||..||:||:::......|..::.....|.:
Zfish   169 RLTFAYTFERMCGQMPAPPSYVPAVALTDHLTDRMSFMERVENMLLYFIHTTVFRLNTMLTVDRL 233

  Fly   226 IRKHFSSLLPRVPTVKQLEQNISVILLNSYMPLTSPRPMSQNMISVGGLHILPPKPLPEHIKNYL 290
                ::.:..:..|:.:......:.|:.:|.....|||...|...|||||..|.|||.:.::.::
Zfish   234 ----YTEIRGKPTTMCETMGKADIWLIRTYWDFEYPRPFPPNFKFVGGLHCKPAKPLSKEMEEFV 294

  Fly   291 DNA-EHGAIYFSLGSQVRSADMPAEKLQIFLDVFASLKQRVLWKFEDDQLPNLPDNVKVEKWLPQ 354
            .:: :||.:.|||||.::  ::.:|:..........:.|:|:|::.......|..|.|:..|:||
Zfish   295 QSSGDHGVVVFSLGSMIK--NLTSERANTIAAALGQIPQKVVWRYSGKTPETLAPNTKIYDWIPQ 357

  Fly   355 ADILAHPNVKVFIAHGGLFGMQEAVYHAVPVLGMPFYFDQDINIKAGQAAGYAIGLDYRTISKDQ 419
            .|:|.||..|.||.|||..|:.||:||.||::|:|.:.||..|:...:..|.|:.||..|:....
Zfish   358 NDLLGHPKTKAFITHGGTNGLYEAIYHGVPMVGLPLFADQPDNLLHMKTKGAAVVLDINTLESKD 422

  Fly   420 LKSALHALLKDPKYQANMMKASRIFRDRPLGAMDTAMYWINYVVEHRGAPHLVAAGVHLPWYQFY 484
            |..||..:|.:|.|:.::|:.|||..|:|:..:|.|:|||.:|:.::||.||......|.|||::
Zfish   423 LVDALKTVLNNPSYKESIMRLSRIHHDQPMKPLDQAVYWIEFVMRNKGAKHLRVQAHELSWYQYH 487

  Fly   485 LLDVSAIILAITLLPLLTLYAVSRNYKSFRGIRAQKKEAKTE 526
            .|||:|.:|:|..| :..|:..:..:...|.:|..:.|.||:
Zfish   488 CLDVAAFLLSIAAL-ITFLWVKACCFLFRRCVRKTRPERKTQ 528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ugt49B2	NP_001097859.4	egt	1..502	CDD:223071	153/536 (29%)
Ugt49B2	NP_001097859.4	UDPGT	31..497	CDD:278624	143/503 (28%)
ugt2a4	NP_001170804.2	UDPGT	21..520	CDD:278624	149/537 (28%)
ugt2a4	NP_001170804.2	egt	<255..486	CDD:223071	84/232 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	252	1.000	Domainoid score	I2043
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	252	1.000	Inparanoid score	I3189
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000004
OrthoInspector	1	1.000	-	-		mtm6444
orthoMCL	1	0.900	-	-		OOG6_100052
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X13
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.860